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1. EP3797425 - INHALER SYSTEM

Office
European Patent Office
Application Number 20724938
Application Date 30.04.2020
Publication Number 3797425
Publication Date 31.03.2021
Publication Kind A1
IPC
G16H 50/30
GPHYSICS
16INFORMATION AND COMMUNICATION TECHNOLOGY SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
HHEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
50ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics
30for calculating health indices; for individual health risk assessment
A61B 5/087
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
BDIAGNOSIS; SURGERY; IDENTIFICATION
5Measuring for diagnostic purposes; Identification of persons
08Measuring devices for evaluating the respiratory organs
087Measuring breath flow
A61M 15/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
15Inhalators
G16H 20/13
GPHYSICS
16INFORMATION AND COMMUNICATION TECHNOLOGY SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
HHEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
20ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance
10relating to drugs or medications, e.g. for ensuring correct administration to patients
13delivered from dispensers
CPC
G16H 50/30
GPHYSICS
16INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
HHEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
50ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics
30for calculating health indices; for individual health risk assessment
A61B 5/087
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
BDIAGNOSIS; SURGERY; IDENTIFICATION
5Measuring for diagnostic purposes
08Detecting, measuring or recording devices for evaluating the respiratory organs
087Measuring breath flow
G16H 20/13
GPHYSICS
16INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
HHEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
20ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance
10relating to drugs or medications, e.g. for ensuring correct administration to patients
13delivered from dispensers
A61K 9/0073
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
0012Galenical forms characterised by the site of application
007Pulmonary tract; Aromatherapy
0073Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy;
A61P 11/08
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
11Drugs for disorders of the respiratory system
08Bronchodilators
A61P 11/06
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
11Drugs for disorders of the respiratory system
06Antiasthmatics
Applicants NORTON WATERFORD LTD
Inventors MILTON-EDWARDS MARK
SAFIOTI GUILHERME
GRANOVSKY LENA
REICH MICHAEL
Designated States
Priority Data 201906078 30.04.2019 GB
201910776 29.07.2019 GB
201919070 20.12.2019 GB
201919076 20.12.2019 GB
201919081 20.12.2019 GB
202003534 11.03.2020 GB
Title
(DE) INHALATIONSSYSTEM
(EN) INHALER SYSTEM
(FR) SYSTÈME D'INHALATEUR
Abstract
(EN) Provided is a system (10) for determining a probability of an asthma exacerbation in a subject. The system comprises a first inhaler (100) for delivering a rescue medicament to the subject. The rescue medicament may be suitable for treating the subject's acute respiratory disease, for example by effecting rapid dilation of the bronchi and bronchioles upon inhalation of the medicament. The first inhaler has a use-detection system (12B) configured to determine a rescue inhalation performed by the subject using the first inhaler. The system optionally includes a second inhaler for delivering a maintenance medicament to the subject during a routine inhalation. A sensor system (12A) is configured to measure a parameter relating to airflow during the rescue inhalation and/or during the routine inhalation, when the second inhaler is included in the system. The system further comprises a processor (14) configured to determine a number of the rescue inhalations during a first time period, and receive the parameter measured for at least some of the rescue and/or routine inhalations. The processor then determines, using a weighted model, the probability of the asthma exacerbation based on the number of rescue inhalations and the parameters. The model is weighted such that the number of rescue inhalations is more significant in the probability determination than the parameters. Further provided is a method for determining the probability of an asthma exacerbation in a subject, which method employs the weighted model.
(FR) L'invention concerne un système (10) pour déterminer une probabilité d'une exacerbation de l'asthme chez un sujet. Le système comprend un premier inhalateur (100) pour administrer un médicament de secours au sujet. Le médicament de secours peut être approprié pour traiter la maladie respiratoire aiguë du sujet, par exemple en effectuant une dilatation rapide des bronches et des bronchioles lors de l'inhalation du médicament. Le premier inhalateur comprend un système de détection d'utilisation (12B) configuré pour déterminer une inhalation de secours effectuée par le sujet à l'aide du premier inhalateur. Le système comprend éventuellement un second inhalateur pour administrer un médicament de maintenance au sujet pendant une inhalation de routine. Un système de capteur (12A) est configuré pour mesurer un paramètre relatif à l'écoulement d'air pendant l'inhalation de secours et/ou pendant l'inhalation de routine, lorsque le second inhalateur est inclus dans le système. Le système comprend en outre un processeur (14) configuré pour déterminer un certain nombre des inhalations de secours pendant une première période de temps, et recevoir le paramètre mesuré pour au moins certaines des inspirations de secours et/ou de routine. Le processeur détermine ensuite, à l'aide d'un modèle pondéré, la probabilité de l'exacerbation de l'asthme sur la base du nombre d'inhalations de secours et des paramètres. Le modèle est pondéré de telle sorte que le nombre d'inhalations de secours est plus significatif dans la détermination de probabilité que les paramètres. L'invention concerne en outre un procédé pour déterminer la probabilité d'une exacerbation de l'asthme chez un sujet, lequel procédé utilise le modèle pondéré.