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1. EP3782989 - DETOMIDINE HYDROCHLORIDE MONOHYDRATE

Office European Patent Office
Application Number 19193476
Application Date 23.08.2019
Publication Number 3782989
Publication Date 24.02.2021
Publication Kind A1
IPC
C07D 233/64
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
233Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
54having two double bonds between ring members or between ring members and non-ring members
64with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
A61K 31/4174
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
41having five-membered rings with two or more ring hetero atoms, at least one of which is nitrogen, e.g. tetrazole
41641,3-Diazoles
4174Arylalkylimidazoles, e.g. oxymetazolin, naphazoline, miconazole
A61P 25/20
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25Drugs for disorders of the nervous system
20Hypnotics; Sedatives
CPC
A61P 25/20
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25Drugs for disorders of the nervous system
20Hypnotics; Sedatives
C07D 233/64
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
233Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
54having two double bonds between ring members or between ring members and non-ring members
64with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
Applicants SACHSE ANDREAS
Inventors SACHSE ANDREAS
Designated States
Priority Data 19193476 23.08.2019 EP
Title
(DE) DETOMIDIN-HYDROCHLORID-MONOHYDRAT
(EN) DETOMIDINE HYDROCHLORIDE MONOHYDRATE
(FR) MONOHYDRATE D'HYDROCHLORURE DE DETOMIDINE
Abstract
(EN)
The present invention relates to detomidine hydrochloride monohydrate, a method for the production of the same and to the use of the same as a medicament, that is for use as anesthetic, analgesic, muscle relaxant, sedative and any other condition susceptible to treatment with an alpha2-adrenoreceptor agonist in a mammal.Detomidine hydrochloride monohydrate described herein represents the pure monohydrate form which additionally shows a high purity reflected the very low content of impurities and especially residual solvents. Correspondingly, detomidine hydrochloride monohydrate described herein, shows a very high storage stability which is useful for the production of pharmaceutical compositions for the treatment of pathological conditions.

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