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199. (EP2393804) NOVEL SUBSTITUTED BICYCLIC HETEROCYCLIC COMPOUNDS AS GAMMA SECRETASE MODULATORS

Application Number: 10701701 Application Date: 02.02.2010
Publication Number: 2393804 Publication Date: 14.12.2011
Publication Kind : B1
Designated States: AL,AT,BA,BE,BG,CH,CY,CZ,DE,DK,EE,ES,FI,FR,GB,GR,HR,HU,IE,IS,IT,LI,LT,LU,LV,MC,MK,MT,NL,NO,PL,PT,RO,RS,SE,SI,SK,SM,TR
Prior PCT appl.: Application Number:EP2010051244 ; Publication Number: Click to see the data
IPC:
C07D 403/10
A61K 31/4353
A61P 25/28
C07D 413/10
C07D 487/04
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
403
Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/167
02
containing two hetero rings
10
linked by a carbon chain containing aromatic rings
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
435
having six-membered rings with one nitrogen as the only ring hetero atom
4353
ortho- or peri-condensed with heterocyclic ring systems
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25
Drugs for disorders of the nervous system
28
for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
413
Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
02
containing two hetero rings
10
linked by a carbon chain containing aromatic rings
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
487
Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/-C07D477/183
02
in which the condensed system contains two hetero rings
04
Ortho-condensed systems
Applicants: JANSSEN PHARMACEUTICALS INC
CELLZOME LTD
Inventors: GIJSEN HENRICUS JACOBUS MARIA
VELTER ADRIANA INGRID
MACDONALD GREGOR JAMES
BISCHOFF FRANCOIS PAUL
WU TONGFEI
VAN BRANDT SVEN FRANCISCUS ANNA
SURKYN MICHEL
ZAJA MIRKO
PIETERS SERGE MARIA ALOYSIUS
BERTHELOT DIDIER JEAN-CLAUDE
DE CLEYN MICHEL ANNA JOZEF
OEHLRICH DANIEL
Priority Data: 09152254 06.02.2009 EP
10701701 02.02.2010 EP
2010051244 02.02.2010 EP
Title: (FR) Nouveaux composés hétérocycliques bicycliques substitués en tant que modulateurs de la secrétase gamma
(EN) NOVEL SUBSTITUTED BICYCLIC HETEROCYCLIC COMPOUNDS AS GAMMA SECRETASE MODULATORS
(DE) Neuartige substituierte bicyclische/heterocyclische Verbindungen als gamma-Secretase-Modulatoren
Abstract:
(FR) La présente invention porte sur des composés hétérocycliques bicycliques substitués de formule (I) dans laquelle Het1, Het2, A1, A2, A3 et A4 ont la signification définie dans les revendications. Les composés selon la présente invention sont utiles comme modulateurs de la gamma-sécrétase. L'invention porte en outre sur des procédés de préparation de tels nouveaux composés, sur des compositions pharmaceutiques comprenant lesdits composés en tant que principe actif ainsi que sur l'utilisation desdits composés comme médicament.
(EN) The present invention is concerned with substituted bicyclic heterocyclic compounds of Formula (I) wherein Het1, Het2, A1, A2, A3 and A4 have the meaning defined in the claims. The compounds according to the present invention are useful as gamma secretase modulators. The invention further relates to processes for preparing such novel compounds, pharmaceutical compositions comprising said compounds as an active ingredient as well as the use of said compounds as a medicament.