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1. EP2385939 - DIHYDROPYRIDONE AMIDES AS P2X7 MODULATORS

Office European Patent Office
Application Number 09775181
Application Date 14.12.2009
Publication Number 2385939
Publication Date 16.11.2011
Publication Kind A1
IPC
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
401
Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
02
containing two hetero rings
12
linked by a chain containing hetero atoms as chain links
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
435
having six-membered rings with one nitrogen as the only ring hetero atom
44
Non-condensed pyridines; Hydrogenated derivatives thereof
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
413
Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
02
containing two hetero rings
12
linked by a chain containing hetero atoms as chain links
C07D 401/12
A61K 31/44
C07D 413/12
CPC
C07D 401/12
C07D 413/12
Applicants HOFFMANN LA ROCHE
Inventors BERGER JACOB
CAROON JOAN MARIE
KRAUSS NANCY ELISABETH
LOPEZ-TAPIA FRANCISCO JAVIER
WALKER KEITH ADRIAN MURRAY
ZHAO SHU-HAI
Priority Data 203482 P null
EP2009067026 null
US20080203482P null
WO2009EP67026 null
09775181 14.12.2009 EP
20348208 23.12.2008 US
Title
(DE) DIHYDROPYRIDONAMIDINE ALS P2X7-MODULATOREN
(EN) DIHYDROPYRIDONE AMIDES AS P2X7 MODULATORS
(FR) AMIDES DE DIHYDROPYRIDONE UTILES COMME MODULATEURS DE P2X7
Abstract
(EN)
Compounds of the formula I: or pharmaceutically acceptable salts thereof, wherein m, n, R1, R2, R3, R4, R5 and Ra are as defined herein. Also disclosed are methods of making the compounds and using the compounds for treatment of diseases associated with the P2X7 purinergic receptor.

(FR)
La présente invention concerne des composés de formule I ou leurs sels pharmaceutiquement acceptables, dans laquelle m, n, R1, R2, R3, R4, R5 et Ra sont tels que définis dans le présent document. La présente invention concerne en outre des procédés de fabrication des composés et d'utilisation des composés pour le traitement de maladies associées au récepteur purinergique P2X7.

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