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1. EP3681480 - PROCESS FOR PREPARING NANOLIPOSOMES COMPRISING MICRONUTRIENTS AND FOOD PRODUCTS COMPRISING SAID NANOLIPOSOMES

Office
European Patent Office
Application Number 18783143
Application Date 06.09.2018
Publication Number 3681480
Publication Date 22.07.2020
Publication Kind A1
IPC
A61K 9/127
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
10Dispersions; Emulsions
127Liposomes
A23L 33/16
AHUMAN NECESSITIES
23FOODS OR FOODSTUFFS; THEIR TREATMENT, NOT COVERED BY OTHER CLASSES
LFOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D91; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
33Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
10using additives
16Inorganic salts, minerals or trace elements
CPC
A23L 29/10
AHUMAN NECESSITIES
23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
LFOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A23B - A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT
29Foods or foodstuffs containing additives
10containing emulsifiers
A23L 33/115
AHUMAN NECESSITIES
23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
LFOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A23B - A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT
33Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
10using additives
115Fatty acids or derivatives thereof; Fats or oils
A23L 33/15
AHUMAN NECESSITIES
23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
LFOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A23B - A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT
33Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
10using additives
15Vitamins
A23L 33/16
AHUMAN NECESSITIES
23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
LFOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A23B - A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT
33Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
10using additives
16Inorganic salts, minerals or trace elements
A61K 9/1277
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
10Dispersions; Emulsions
127Liposomes
1277Processes for preparing; Proliposomes
A61K 33/26
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
33Medicinal preparations containing inorganic active ingredients
24Heavy metals; Compounds thereof
26Iron; Compounds thereof
Applicants ENG4LIFE S R L
Inventors BARBA ANNA ANGELA
LAMBERTI GAETANO
D'AMORE MATTEO
BOCHICCHIO SABRINA
DALMORO ANNALISA
Designated States
Title
(DE) VERFAHREN ZUR HERSTELLUNG VON NANOLIPOSOMEN MIT MIKRONÄHRSTOFFEN UND LEBENSMITTELPRODUKTE MIT BESAGTEN NANOLIPOSOMEN
(EN) PROCESS FOR PREPARING NANOLIPOSOMES COMPRISING MICRONUTRIENTS AND FOOD PRODUCTS COMPRISING SAID NANOLIPOSOMES
(FR) PROCÉDÉ DE PRÉPARATION DE NANOLIPOSOMES COMPRENANT DES MICRONUTRIMENTS ET PRODUITS ALIMENTAIRES COMPRENANT LESDITS NANOLIPOSOMES
Abstract
(EN)
The invention relates to a continuous or semi-continuous, high productivity process for obtaining nanoliposomes containing iron (ll) combined with a reducing agent capable of increasing the stability and bioavailability of iron (ll), such as ascorbic acid or a salt thereof, which process is based on a high productivity "simil-microfluidic" technique for nanoliposome formation, coupled with an ultrasound treatment for the homogenization of the nanoliposomes obtained. The invention also concerns the nanoliposomes obtained by means of the described process, and the food and nutraceutical products enriched with iron(ll), in which enrichment is accomplished by using said nanoliposomes as a source of bioavailable iron.

(FR)
L'invention concerne un procédé continu ou semi-continu à productivité élevée permettant d'obtenir des nanoliposomes contenant du fer (ll) combiné à un agent réducteur susceptible d'augmenter la stabilité et la biodisponibilité du fer (ll), tel que l'acide ascorbique ou un sel de celui-ci, lequel procédé est basé sur une technique « de type simil-microfluidique » à productivité élevée pour la formation de nanoliposomes, combinée à un traitement par ultrasons pour l'homogénéisation des nanoliposomes obtenus. L'invention concerne également les nanoliposomes obtenus au moyen du procédé décrit, et les produits alimentaires et nutraceutiques enrichis en fer (ll), dans lesquels l'enrichissement est réalisé en utilisant lesdits nanoliposomes en tant que source de fer biodisponible.

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