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1. (EP3414692) HIGH-THROUGHPUT IDENTIFICATION OF PATIENT-SPECIFIC NEOEPITOPES AS THERAPEUTIC TARGETS FOR CANCER IMMUNOTHERAPIES

Office : European Patent Office
Application Number: 17750909 Application Date: 10.02.2017
Publication Number: 3414692 Publication Date: 19.12.2018
Publication Kind : A1
Designated States: AL, AT, BA, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LI, LT, LU, LV, MC, ME, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR
Prior PCT appl.: Application Number:US2017017549 ; Publication Number: Click to see the data
IPC:
G06F 19/18
A61K 35/17
A61K 39/00
A61K 39/395
A61K 47/50
A61K 48/00
C12Q 1/68
G01N 33/569
G01N 33/574
G PHYSICS
06
COMPUTING; CALCULATING; COUNTING
F
ELECTRIC DIGITAL DATA PROCESSING
19
Digital computing or data processing equipment or methods, specially adapted for specific applications
10
Bioinformatics, i.e. methods or systems for genetic or protein-related data processing in computational molecular biology
18
for functional genomics or proteomics, e.g. genotype-phenotype associations, linkage disequilibrium, population genetics, binding site identification, mutagenesis, genotyping or genome annotation, protein-protein interactions or protein-nucleic acid interactions
[IPC code unknown for A61K 35/17]
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39
Medicinal preparations containing antigens or antibodies
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39
Medicinal preparations containing antigens or antibodies
395
Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
[IPC code unknown for A61K 47/50]
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
48
Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
Q
MEASURING OR TESTING PROCESSES INVOLVING ENZYMES OR MICRO-ORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1
Measuring or testing processes involving enzymes or micro-organisms; Compositions therefor; Processes of preparing such compositions
68
involving nucleic acids
G PHYSICS
01
MEASURING; TESTING
N
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33
Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48
Biological material, e.g. blood, urine; Haemocytometers
50
Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
53
Immunoassay; Biospecific binding assay; Materials therefor
569
for micro-organisms, e.g. protozoa, bacteria, viruses
G PHYSICS
01
MEASURING; TESTING
N
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33
Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48
Biological material, e.g. blood, urine; Haemocytometers
50
Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
53
Immunoassay; Biospecific binding assay; Materials therefor
574
for cancer
CPC:
G16B 20/00
A61K 35/17
A61K 39/00
A61K 39/0011
A61K 39/395
A61K 39/39558
A61K 45/06
A61K 47/6851
A61K 48/00
C12Q 1/6886
C12Q 2600/106
C12Q 2600/156
G06F 19/18
Applicants: NANTOMICS LLC
NANT HOLDINGS IP LLC
Inventors: NGUYEN ANDREW
SANBORN JOHN ZACHARY
BENZ STEPHEN CHARLES
NIAZI KAYVAN
RABIZADEH SHAHROOZ
SOON-SHIONG PATRICK
VASKE CHARLES JOSEPH
Priority Data: 201662294665 12.02.2016 US
2017017549 10.02.2017 US
Title: (DE) HOCHDURCHSATZIDENTIFIZIERUNG VON PATIENTENSPEZIFISCHEN NEOEPITOPEN ALS THERAPEUTISCHE ZIELE FÜR KREBSIMMUNTHERAPIEN
(EN) HIGH-THROUGHPUT IDENTIFICATION OF PATIENT-SPECIFIC NEOEPITOPES AS THERAPEUTIC TARGETS FOR CANCER IMMUNOTHERAPIES
(FR) IDENTIFICATION À HAUT DÉBIT DE NÉOÉPITOPES SPÉCIFIQUES AU PATIENT EN TANT QUE CIBLES THÉRAPEUTIQUES POUR LES IMMUNOTHÉRAPIES DU CANCER
Abstract:
(EN) Systems and methods are presented that allow for selection of tumor neoepitopes that are filtered for various criteria. In particularly contemplated aspects, filtering includes a step in which the mutation leading to the neoepitope is ascertained as being located in a cancer driver gene.
(FR) L'invention concerne des systèmes et des procédés permettant de sélectionner des néoépitopes tumoraux qui sont filtrés selon différents critères. Dans des aspects particuliers de l'invention, le filtrage comprend une étape dans laquelle il est déterminé que la mutation conduisant au néoépitope se situe dans un gène cancérigène.
Also published as:
AU2017217877CA3014252SG11201806282XKR1020180091119CN108701172IL261090
US20190034582WO/2017/139694