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1. EP3407904 - BOTANICAL COMPOSITIONS OF SALVIA OFFICINALIS WITH ACTIVITY IN EXTENDING CHRONOLOGICAL LIFESPAN AND USES THEREOF

Office
European Patent Office
Application Number 17707095
Application Date 27.01.2017
Publication Number 3407904
Publication Date 05.12.2018
Publication Kind B1
IPC
A61K 36/537
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
36Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
18Magnoliophyta (angiosperms)
185Magnoliopsida (dicotyledons)
53Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
537Salvia (sage)
A61P 19/10
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
19Drugs for skeletal disorders
08for bone diseases, e.g. rachitism, Paget's disease
10for osteoporosis
A61P 21/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
21Drugs for disorders of the muscular or neuromuscular system
A61P 25/28
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25Drugs for disorders of the nervous system
28for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
A61P 35/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35Antineoplastic agents
A61P 43/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
43Drugs for specific purposes, not provided for in groups A61P1/-A61P41/108
CPC
A61K 36/537
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
36Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
18Magnoliophyta (angiosperms)
185Magnoliopsida (dicotyledons)
53Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
537Salvia (sage)
A61P 25/28
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25Drugs for disorders of the nervous system
28for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
A61P 43/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
43Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
A61P 39/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
39General protective or antinoxious agents
A61K 9/0053
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
0012Galenical forms characterised by the site of application
0053Mouth and digestive tract, i.e. intraoral and peroral administration
A61K 49/0008
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
49Preparations for testing in vivo
0004Screening or testing of compounds for diagnosis of disorders, assessment of conditions, e.g. renal clearance, gastric emptying, testing for diabetes, allergy, rheuma, pancreas functions
0008Screening agents using (non-human) animal models or transgenic animal models or chimeric hosts, e.g. Alzheimer disease animal model, transgenic model for heart failure
Applicants SIBELIUS LTD
Inventors LEYLAND PETER ANTHONY
AKOULITCHEV ALEXANDRE
VERSLYPE ANTOINE
CAIGER STEPHEN
Designated States
Priority Data 201601520 27.01.2016 GB
Title
(DE) PFLANZLICHE ZUSAMMENSETZUNGEN VON SALVIA OFFICINALIS MIT AKTIVITÄT ZUR VERLÄNGERUNG DER CHRONOLOGISCHEN LEBENSERWARTUNG UND DEREN VERWENDUNG
(EN) BOTANICAL COMPOSITIONS OF SALVIA OFFICINALIS WITH ACTIVITY IN EXTENDING CHRONOLOGICAL LIFESPAN AND USES THEREOF
(FR) COMPOSITIONS BOTANIQUES DE SALVIA OFFICINALIS À ACTIVITÉ PROLONGEANT LA DURÉE DE VIE CHRONOLOGIQUE ET LEUR UTILISATION
Abstract
(EN) Compositions comprising a nutritionally or pharmaceutically effective dosage of an extract of Salvia officinalis and an acceptable carrier are provided. The compositions show particular potential in the treatment of age-related pathologies in humans or animals. The extracts are obtained from varieties and cultivars of Salvia officinalis that possess a unique chemical fingerprint that includes unusually low thujone content in the leaf. When tested in C. elegans screening assays compositions that comprise the extract elicit an increase in mean chronological lifespan (CLS)in the C. elegans population of at least 10%.
(FR) L'invention concerne des compositions comprenant une dose efficace sur le plan nutritionnel ou pharmaceutique d'un extrait de Salvia officinalis et un excipient acceptable. Les compositions présentent des possibilités particulières pour le traitement de pathologies liées à l'âge chez l'homme ou l'animal. Les extraits sont obtenus à partir de variétés et de cultivars de Salvia officinalis possédant une empreinte chimique unique de teneur en thuyone de la feuille exceptionnellement basse. Lors de dosages de criblage de C. elegans, les compositions comprenant l'extrait induisent une augmentation de la durée de vie chronologique (CLS) moyenne de la population de C. elegans d'au moins 10 %.