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1. (EP3384075) A METHOD OF RESIDUE PROXIMITY INFORMATION AND PROTEIN MODEL DISCRIMINATION USING SATURATION-SUPPRESSOR MUTAGENESIS

Office : European Patent Office
Application Number: 16870141 Application Date: 18.11.2016
Publication Number: 3384075 Publication Date: 10.10.2018
Publication Kind : A4
Designated States: AL, AT, BA, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LI, LT, LU, LV, MC, ME, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR
Prior PCT appl.: Application Number:IN2016050413 ; Publication Number: Click to see the data
IPC:
C40B 20/00
C12N 15/10
C40B 10/00
C CHEMISTRY; METALLURGY
40
COMBINATORIAL TECHNOLOGY
B
COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES, IN SILICO LIBRARIES
20
Methods specially adapted for identifying library members
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15
Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09
Recombinant DNA-technology
10
Processes for the isolation, preparation or purification of DNA or RNA
C CHEMISTRY; METALLURGY
40
COMBINATORIAL TECHNOLOGY
B
COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES, IN SILICO LIBRARIES
10
Directed molecular evolution of macromolecules, e.g. RNA, DNA or proteins
CPC:
C12N 15/10
C12N 15/1058
C40B 10/00
C40B 20/00
Applicants: INDIAN INST SCIENT
Inventors: RAGHAVAN VARADARAJAN
SAHOO ANUSMITA
KHARE SHRUTI
JAIN PANKAJ
AHMED SHAHBAZ
GUPTA KRITIKA
Priority Data: 2016050413 18.11.2016 IN
6466CH2015 01.12.2015 IN
Title: (DE) VERFAHREN FÜR RESTNÄHEINFORMATIONEN UND PROTEINMODELLUNTERSCHEIDUNG MITTELS SÄTTIGUNGS-SUPPRESSOR-MUTAGENESE
(EN) A METHOD OF RESIDUE PROXIMITY INFORMATION AND PROTEIN MODEL DISCRIMINATION USING SATURATION-SUPPRESSOR MUTAGENESIS
(FR) PROCÉDÉ DE DISCRIMINATION DE MODÈLE PROTÉIQUE ET D'INFORMATIONS DE PROXIMITÉ DE RÉSIDU AU MOYEN D'UNE MUTAGÉNÈSE DE SUPPRESSION PAR SATURATION
Abstract:
(EN) The present disclosure relates to a method of protein structure and amino acid residue interaction prediction based on saturation suppressor mutagenesis screening of a protein of interest. The method of the instant disclosure can be adapted for multi- protein complexes, and is useful where crystal structure of a protein of interest is not available.
(FR) La présente invention concerne un procédé de prédiction d'interaction entre une structure protéique et un résidu d'acides aminés sur la base d'un criblage de mutagénèse de suppression par saturation d'une protéine d'intérêt. Le procédé selon la présente invention peut être conçu pour des complexes multiprotéiques et est utile lorsque la structure cristalline d'une protéine d'intérêt n'est pas disponible.
Also published as:
WO/2017/094024