EP3380104 AN A3 ADENOSINE RECEPTOR LIGAND FOR USE IN TREATING ECTOPIC FAT ACCUMULATION

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European Patent Office

Application Number 16806299

Application Date 22.11.2016

Publication Number 3380104

Publication Date 03.10.2018

Publication Kind B1

IPC

CPC

Applicants CAN FITE BIOPHARMA LTD

Inventors FISHMAN PNINA
COHEN SHIRA

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Priority Data 242723 23.11.2015 IL

Title

(DE) ADENOSIN-A3-REZEPTORLIGAND ZUR BEHANDLUNG VON EKTOPISCHER FETTANHÄUFUNG

(EN) AN A3 ADENOSINE RECEPTOR LIGAND FOR USE IN TREATING ECTOPIC FAT ACCUMULATION

(FR) LIGAND DU RECEPTEUR ADENOSINE A3 POUR LE TRAITEMENT DE L'ACCUMULATION DE GRAISSE ECTOPIQUE

Abstract

(EN) The present disclosure concerns A₃AR ligand for reducing ectopic fat accumulation, particularly in fatty liver. Also provided by the present disclosure is the use of A₃AR ligand for the preparation of a pharmaceutical composition for reducing such fat accumulation, method of treating a condition associates with fat accumulation making use of the ligand and kits comprising pharmaceutical compositions comprising the ligand, and instructions for use of same, for treating a condition associated with ectopic fat accumulation. In one embodiment, the present disclosure provides the use of an A₃AR agonist, such as 2-Chloro-N⁶-(3-iodobenzyl)-adenosine-5'-N-methyluronamide (C1-IB-MECA, CF102) for treating fatty liver, specifically, non-alcoholic fatty liver disease (NAFLD).

(FR) La présente invention concerne le ligand du récepteur de l'adénosine A₃ pour réduire l'accumulation de graisse ectopique, en particulier dans la stéatose hépatique. La présente invention concerne également l'utilisation du ligand du récepteur de l'adénosine A₃ pour la préparation d'une composition pharmaceutique permettant de réduire l'accumulation de graisse, une méthode de traitement d'un état associé à l'accumulation de graisse utilisant le ligand et des trousses comprenant des compositions pharmaceutiques comprenant le ligand, et des instructions concernant leur utilisation, pour traiter un état associé à l'accumulation de graisse ectopique. Dans un mode de réalisation, la présente invention porte sur l'utilisation d'un agoniste du récepteur de l'adénosine A₃, tel que le 2-chloro-N⁶-(3-iodobenzyl) -adénosine-5 '-N-méthyluronamide (C1-IB-MECA, CF102) pour le traitement de la stéatose hépatique, en particulier, la stéatose hépatique non alcoolique (NAFLD).

A	HUMAN NECESSITIES
61	MEDICAL OR VETERINARY SCIENCE; HYGIENE
K	PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31	Medicinal preparations containing organic active ingredients
70	Carbohydrates; Sugars; Derivatives thereof
7042	Compounds having saccharide radicals and heterocyclic rings
7052	having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
706	containing six-membered rings with nitrogen as a ring hetero atom
7064	containing condensed or non-condensed pyrimidines
7076	containing purines, e.g. adenosine, adenylic acid

A	HUMAN NECESSITIES
61	MEDICAL OR VETERINARY SCIENCE; HYGIENE
K	PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9	Medicinal preparations characterised by special physical form

A	HUMAN NECESSITIES
61	MEDICAL OR VETERINARY SCIENCE; HYGIENE
P	SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
1	Drugs for disorders of the alimentary tract or the digestive system
16	for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics

A	HUMAN NECESSITIES
61	MEDICAL OR VETERINARY SCIENCE; HYGIENE
K	PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31	Medicinal preparations containing organic active ingredients
70	Carbohydrates; Sugars; Derivatives thereof
7042	Compounds having saccharide radicals and heterocyclic rings
7052	having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
706	containing six-membered rings with nitrogen as a ring hetero atom
7064	containing condensed or non-condensed pyrimidines
7076	containing purines, e.g. adenosine, adenylic acid

A	HUMAN NECESSITIES
61	MEDICAL OR VETERINARY SCIENCE; HYGIENE
K	PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9	Medicinal preparations characterised by special physical form

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1. EP3380104 - AN A3 ADENOSINE RECEPTOR LIGAND FOR USE IN TREATING ECTOPIC FAT ACCUMULATION