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1. (EP3351269) SELF-BUFFERING PROTEIN FORMULATIONS

Office : European Patent Office
Application Number: 17205734 Application Date: 08.06.2006
Publication Number: 3351269 Publication Date: 25.07.2018
Publication Kind : A1
Designated States: AL, AT, BA, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LI, LT, LU, LV, MC, MK, NL, PL, PT, RO, RS, SE, SI, SK, TR
IPC:
A61K 39/395
A61K 9/08
C12P 21/08
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39
Medicinal preparations containing antigens or antibodies
395
Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9
Medicinal preparations characterised by special physical form
08
Solutions
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
P
FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
21
Preparation of peptides or proteins
08
Monoclonal antibodies
CPC:
A61K 39/3955
A61K 9/08
A61K 39/39591
A61K 47/02
A61K 47/10
A61K 47/26
C07K 16/00
C07K 16/241
C07K 16/2803
C07K 16/2827
C07K 16/2851
C07K 16/2866
C07K 16/2875
C07K 2317/21
C07K 2317/565
C07K 2317/94
Applicants: AMGEN INC
Inventors: GOKARN YATIN R
KRAS EVA
BREMS DAVID N
REMMELE RICHARD LOUIS JR
HERSHENSON SUSAN IRENE
Priority Data: 06772779 08.06.2006 EP
2006022599 08.06.2006 US
69058205 14.06.2005 US
Title: (DE) SELBSTPUFFERNDE PROTEINFORMULIERUNGEN
(EN) SELF-BUFFERING PROTEIN FORMULATIONS
(FR) FORMULATIONS DE PROTÉINE À TAMPONNAGE SPONTANÉ
Abstract: front page image
(EN) The invention herein described, provides, among other things, self-buffering protein formulations. Particularly, the invention provides self-buffering pharmaceutical protein formulations that are suitable for veterinary and human medical use. The self-buffering protein formulations are substantially free of other buffering agents, stably maintain pH for the extended time periods involved in the distribution and storage of pharmaceutical proteins for veterinary and human medical use. The invention further provides methods for designing, making, and using the formulation. In addition to other advantages, the formulations avoid the disadvantages associated with the buffering agents conventionally used in current formulations of proteins for pharmaceutical use. The invention in these and other respects can be productively applied to a wide variety of proteins and is particularly useful for making and using self-buffering formulations of pharmaceutical proteins for veterinary and medical use, especially, in particular, for the treatment of diseases in human subjects.
Also published as:
MXMX/a/2007/015476KR1020080031684IL188102SG162788EP1909831ZA2008/00338
JP2008543839US20080311078BRPI0611901JP2013047261CN101217979CA2610839
EA200800050JP2016053061AU2006259664AU2012272950AU2015242973AU2017202889
IN5286/CHENP/2007JP2018048196WO/2006/138181