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1. EP3337902 - 3' UTR SEQUENCES FOR STABILIZATION OF RNA

Office
European Patent Office
Application Number 16778784
Application Date 05.10.2016
Publication Number 3337902
Publication Date 27.06.2018
Publication Kind B1
IPC
C12N 15/67
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09Recombinant DNA-technology
63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
67General methods for enhancing the expression
CPC
A61P 31/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
31Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
A61P 31/04
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
31Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
04Antibacterial agents
A61P 31/10
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
31Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
10Antimycotics
A61P 31/12
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
31Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
12Antivirals
A61P 33/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
33Antiparasitic agents
A61P 35/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35Antineoplastic agents
Applicants BIONTECH RNA PHARMACEUTICALS GMBH
TRON TRANSLATIONALE ONKOLOGIE AN DER UNIV DER JOHANNES GUTENBERG UNIV MAINZ GEMEINNUETZIGE GMBH
Inventors ORLANDINI VON NIESSEN ALEXANDRA
FESSER STEPHANIE
VALLAZZA BRITTA
BEISSERT TIM
KUHN ANDREAS
SAHIN UGUR
POLEGANOV MARCO ALEXANDER
Designated States
Priority Data 2015073180 07.10.2015 EP
Title
(DE) 3'-UTR-SEQUENZEN ZUR STABILISIERUNG VON RNA
(EN) 3' UTR SEQUENCES FOR STABILIZATION OF RNA
(FR) SÉQUENCES 3'UTR POUR LA STABILISATION D'ARN
Abstract
(EN)
The present invention relates to stabilization of RNA, in particular mRNA, and an increase in mRNA translation. The present invention particularly relates to a modification of RNA, in particular in vitro-transcribed RNA, resulting in increased transcript stability and/or translation efficiency. According to the invention, it was demonstrated that certain sequences in the 3'- untranslated region (UTR) of an RNA molecule improve stability and translation efficiency.

(FR)
La présente invention concerne la stabilisation de l'ARN, en particulier de l'ARNm, et une augmentation de la traduction de l'ARNm. La présente invention concerne en particulier une modification de l'ARN, notamment de l'ARN transcrit in vitro, résultant en une plus grande stabilité de transcription et/ou une plus grande efficacité de traduction. Selon l'invention, il a été démontré que certaines séquences dans la région 3' non traduite (UTR) d'une molécule d'ARN amélioraient la stabilité et l'efficacité de traduction.