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1. EP2340840 - Pulse dose Vitamin D drug for the treatment of hyperproliferative skin diseases

Office
European Patent Office
Application Number 10184333
Application Date 25.03.1999
Publication Number 2340840
Publication Date 06.07.2011
Publication Kind B1
IPC
A61K 31/59
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
59Compounds containing 9,10-seco-cyclopentahydro- phenanthrene ring systems
A61P 3/14
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
3Drugs for disorders of the metabolism
12for electrolyte homeostasis
14for calcium homeostasis
A61P 17/06
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
17Drugs for dermatological disorders
06Antipsoriatics
A61P 17/12
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
17Drugs for dermatological disorders
12Keratolytics, e.g. wart or anti-corn preparations
A61P 35/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35Antineoplastic agents
A61P 35/02
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35Antineoplastic agents
02specific for leukemia
CPC
A61K 31/59
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
59Compounds containing 9, 10- seco- cyclopenta[a]hydrophenanthrene ring systems
A61K 31/593
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
59Compounds containing 9, 10- seco- cyclopenta[a]hydrophenanthrene ring systems
5939,10-Secocholestane derivatives, e.g. cholecalciferol, i.e. vitamin D3
A61P 3/14
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
3Drugs for disorders of the metabolism
12for electrolyte homeostasis
14for calcium homeostasis
A61P 17/06
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
17Drugs for dermatological disorders
06Antipsoriatics
A61P 17/12
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
17Drugs for dermatological disorders
12Keratolytics, e.g. wart or anti-corn preparations
A61P 35/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35Antineoplastic agents
Applicants UNIV OREGON HEALTH SCIENCES
Inventors HENNER WILLIAM D
BEER TOMASZ M
Designated States
Priority Data 99914109 25.03.1999 EP
7969698 27.03.1998 US
Title
(DE) Gepulste Dose von einem Vitamin D Wirkstoff zur Behandlung von hyperproliferativen Hauterkrankungen
(EN) Pulse dose Vitamin D drug for the treatment of hyperproliferative skin diseases
(FR) Dose pulsée d'une vitamin D pour le traitement de maladies d'hyperprolifération de la peau
Abstract
(EN)
A vitamin D drug, e.g. calcitriol, is used to manufacture a medicament for the treatment of a hyperproliferative skin disease in a human, wherein the disease responds to treatment with the drug, the human is susceptible to hypercalcemia when the drug is administered at antiproliferative doses, and the medicament is for administration to the human of therapeutically effective pulse doses of the drug not more often than once every three days in an amount to treat the hyperproliferative skin disease, without inducing severe symptomatic hypercalcemia.

(FR)
L'invention concerne le traitement de troubles d'hyperprolifération (notamment de tumeurs et de psoriasis) par l'administration répétée d'un médicament (tel que la vitamine D ou un analogue de celle-ci) qui accroît les taux de vitamine D dans le sang ou dans les tissus. Le médicament est administré en dose suffisante pour produire un effet d'antiprolifération, sans que l'administration répétée du médicament ne provoque le développement d'une hypercalcémie symptomatique grave ou mettant en danger la vie du sujet. Dans des modes de réalisation particuliers, les risques d'hypercalcémie (mesurée par des taux de calcium sérique supérieurs à la normale) sont entièrement écartés. Dans un exemple particulier, le médicament est du calcitriol administré oralement selon une dose d'environ 0,5 mcg/kg, une fois par semaine.