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1. (EP2301533) Wortmannin Analogs and Method of Using Same

Office : European Patent Office
Application Number: 10184151 Application Date: 11.07.2005
Publication Number: 2301533 Publication Date: 30.03.2011
Publication Kind : A8
IPC:
A61K 31/40
A61K 31/352
A61P 35/00
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
40
having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
335
having oxygen as the only ring hetero atom, e.g. fungichromin
35
having six-membered rings with one oxygen as the only ring hetero atom
352
condensed with carbocyclic rings, e.g. cannabinols, methantheline
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35
Antineoplastic agents
CPC:
C07D 311/78
A61K 31/337
A61K 31/35
A61K 31/366
A61K 31/40
A61K 31/4025
A61K 31/7072
A61K 33/24
A61K 45/06
C07D 311/94
Applicants: PROLX PHARMACEUTICALS INC
UNIV ARIZONA
UNIV PITTSBURGH
Inventors: KIRKPATRICK LYNN
POWIS GARTH
WIPF PETER
Priority Data: 05773378 11.07.2005 EP
58668704 09.07.2004 US
Title: (DE) Wortmannin-Analoga und Verfahren zu deren Verwendung
(EN) Wortmannin Analogs and Method of Using Same
(FR) Analogues de la wortmannine et leur procédé d'utilisation
Abstract: front page image
(EN) Wortmannin analogs and their use in inhibiting PI-3-kinase activity in mammals and the treatment of cancer and tumour formation in a subject are described herein. The wortmannin analogs have utility in the treatment of cancer, in particular, lung cancer.
Also published as:
MXMX/a/2007/000319AU2005333515EP1901738JP2009500408CA2578336AU2005333515
WO/2007/008200