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1. (EP2054420) BENZIMIDAZO[1,2-C][1,2,3]THIADIAZOL-7-SULFONAMIDES AS INHIBITORS OF CARBONIC ANHYDRASE AND THE INTERMEDIATES FOR PRODUCTION THEREOF
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Claims

1. Benzimidazo[1,2 -c][1,2,3]thiadiazole sulfonamides of general formula (I)

wherein R is H, Cl, SCH 3, SO 2CH 3, morpholine, tiophenyl, N(CH 3) 2, piperidine, N-methylpiperazine, and where sulfonamide group H 2NO 2S- is in 7 position or 5, 6, 8 position, and pharmaceutically acceptable salts thereof.
  2. Benzimidazo[1,2- c][1,2,3]thiadiazole sulfonamides of general formula (I) according to claim 1, wherein R is H, Cl, SCH 3, SO 2CH 3, morpholine or tiophenyl and where sulfonamide group H 2NO 2S- is in 7 position, and pharmaceutically acceptable salts thereof.
  3. Compound according to claim 2, selected from a group comprising of:

3-chlorobenzimidazo[1,2-c][1,2,3]thiadiazol-7-sulfonamide;

3-morpholinbenzimidazo[1,2-c][1,2,3]thiadiazol-7-sulfonamide;

3-phenylthiobenzimidazo[1,2-c][1,2,3]thiadiazol-7-sulfonamide;

3-methylthiobenzimidazo[1,2-c][1,2,3]thiadiazol-T-sulfonamide;

benzimidazo[1,2-c][1,2,3]thiadiazol-7-sulfonamide;

3-methylsulfonylbenzimidazo[1,2-c][1,2,3]thiadiazol-7-sulfonamide.


  4. 3-chlorobenzimidazo[1,2- c][1,2,3]thiadiazol-7-sulfonyl chloride 2.
  5. 3-methylthiobenzimidazo[1,2- c][1,2,3]thiadiazole 7.
  6. 3-methylthiobenzimidazo[1,2- c][1,2,3]thiadiazol-7-sulfonyl chloride 8.
  7. Benzimidazo[1,2- c][1,2,3]thiadiazole 10.
  8. Benzimidazo[1,2- c][1,2,3]thiadiazol-7-sulfonyl chloride 11.
  9. 3-methylsulfonylbenzimidazo[1,2- c][1,2,3]thiadiazole 13.
  10. 3-methylsulfonylbenzimidazo[1,2- c][1,2,3]thiadiazol-7-sulfonyl chloride 14.
  11. (1-amino-5-bromo-1 H-benzimidazol-2-yl)methanol 17 and (1-amino-6-bromo-1 H-benzimidazol-2-yl)methanol 18.
  12. 3-chloro-6-bromobenzimidazo[1,2- c][1,2,3]thiadiazole 19.
  13. 3-chloro-7-bromobenzimidazo[1,2- c][1,2,3]thiadiazole 20.
  14. Composition for use in control of conditions where inhibition of carbonic anhydrase is necessary, characterized in that it contains effective amount of sulfonamide according to any one of claims 1 to 3.