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1. (EP3115065) METHOD AND SYSTEM FOR PREPARING SOFT TISSUE FOR GRAFTING, ENHANCING GRAFTING RESULTS, AND GRAFTING AUTOLOGOUS FAT AND ADIPOCYTE DERIVED STEM CELLS TO SOFT TISSUE SUCH AS THE BREAST AND OTHER TISSUE DEFECTS

Office : European Patent Office
Application Number: 16185275 Application Date: 23.04.2007
Publication Number: 3115065 Publication Date: 11.01.2017
Publication Kind : A1
Designated States: AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LI, LT, LU, LV, MC, MT, NL, PL, PT, RO, SE, SI, SK, TR
IPC:
A61K 48/00
C12N 5/00
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
48
Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
5
Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
CPC:
A61F 2/12
A61B 90/02
A61B 90/17
A61B 2017/00792
A61B 2017/00796
A61B 2017/00969
A61B 2017/308
A61B 2217/005
A61B 2562/0247
A61F 2210/0004
Applicants: KHOURI ROGER K
Inventors: KHOURI ROGER K
Priority Data: 07761108 23.04.2007 EP
40929406 21.04.2006 US
Title: (DE) VERFAHREN UND SYSTEM ZUR HERSTELLUNG VON WEICHEM GEWEBE ZUR TRANSPLANTATION, VERBESSERUNG DER TRANSPLANTATIONSERGEBNISSE UND TRANSPLANTATION VON AUTOLOGEN STAMMZELLEN AUS FETT UND ADIPOZYTEN AUF GEWEBE, WIE DIE BRUST UND ANDERE GEWEBEDEFEKTE
(EN) METHOD AND SYSTEM FOR PREPARING SOFT TISSUE FOR GRAFTING, ENHANCING GRAFTING RESULTS, AND GRAFTING AUTOLOGOUS FAT AND ADIPOCYTE DERIVED STEM CELLS TO SOFT TISSUE SUCH AS THE BREAST AND OTHER TISSUE DEFECTS
(FR) PROCÉDÉ ET SYSTÈME DE PRÉPARATION DE TISSUS MOUS EN VUE D'UNE GREFFE, AMÉLIORATION DES RÉSULTATS DE GREFFE, ET GREFFE AUTOLOGUE DE CELLULES SOUCHES DÉRIVÉES DU TISSU ADIPEUX ET DES ADIPOCYTES À UN TISSU MOU TEL QUE LE TISSU MAMMAIRE ET D'AUTRES DÉFAUTS TISSULAIRES
Abstract: front page image
(EN) A method is disclosed for preparing a soft tissue site, and augmenting the soft tissue site, such as the breast(s), scar, depression, or other defect, of a subject through use of devices that exert a distractive force on the breast(s) and grafting of autologous fat tissue such as domes with sealing rims for surrounding each of the soft tissue site and a regulated pump. The method for preparing the soft tissue site, and enhancing fat graft results, entails application of the distracting force to the targeted soft tissue site at least intermittently for some period of time and preferably several weeks prior to the graft procedure.; A related aspect of the invention includes following the preparation steps by transfer of fat from other areas of the subject to the subject's soft tissue site, and then reapplication of the distractive force to the soft tissue site that received the autologous fat graft. Alternatively, fat from genetically related sources may be used, and the fat may be further processed prior to injection. Substantial soft tissue augmentation, high rates of graft survival and negligible graft necrosis (data demonstrating 80% survival and only 20% necrosis is presented) or calcification result from the practice of these methods.
Also published as:
EP2029177US20090312746EP3064223WO/2007/124478