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1. EP3072904 - THERAPEUTIC DLL4 BINDING PROTEINS

Office European Patent Office
Application Number 16167670
Application Date 28.02.2011
Publication Number 3072904
Publication Date 28.09.2016
Publication Kind A1
IPC
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
16
Immunoglobulins, e.g. monoclonal or polyclonal antibodies
18
against material from animals or humans
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39
Medicinal preparations containing antigens or antibodies
395
Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15
Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09
Recombinant DNA-technology
11
DNA or RNA fragments; Modified forms thereof
12
Genes encoding animal proteins
13
Immunoglobulins
C07K 16/18
A61K 39/395
C12N 15/13
CPC
C07K 16/28
A61K 39/3955
A61K 45/06
A61K 2039/505
C07K 2317/24
C07K 2317/73
Applicants ABBVIE INC
Inventors LI YINGCHUN
GU JIJIE JAMES
MORGAN-LAPPE SUSAN
CHEN MINGJIU
HSIEH CHUNG-MING
Designated States
Priority Data 11751147 28.02.2011 EP
30949410 02.03.2010 US
Title
(DE) THERAPEUTISCHE DLL4-BINDENDE PROTEINE
(EN) THERAPEUTIC DLL4 BINDING PROTEINS
(FR) PROTÉINES DE LIAISON DLL4 THÉRAPEUTIQUES
Abstract
(EN)
DLL4 binding proteins are described herein, including antibodies, CDR-grafted antibodies, humanized antibodies, and DLL4 binding fragments thereof, proteins that bind DLL4 with high affinity, and DLL4 binding proteins that neutralize DLL4 and/or VEGF activity. The DLL4 binding proteins are useful for treating or preventing cancers and tumors and especially for treating or preventing tumor angiogenesis.