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1. EP3047267 - DIALYSIS CELL FOR AN IN-VITRO RELEASE TEST APPARATUS, USE OF THE DIALYSIS CELL AND IN-VITRO RELEASE TEST APPARATUS

Office
European Patent Office
Application Number 14766913
Application Date 17.09.2014
Publication Number 3047267
Publication Date 27.07.2016
Publication Kind B1
IPC
G01N 33/15
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
15Medicinal preparations
B01D 61/28
BPERFORMING OPERATIONS; TRANSPORTING
01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
DSEPARATION
61Processes of separation using semi-permeable membranes, e.g. dialysis, osmosis or ultrafiltration; Apparatus, accessories or auxiliary operations specially adapted therefor
24Dialysis
28Apparatus therefor
G01N 13/00
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
13Investigating surface or boundary effects, e.g. wetting power; Investigating diffusion effects; Analysing materials by determining surface, boundary, or diffusion effects
CPC
B01D 61/28
BPERFORMING OPERATIONS; TRANSPORTING
01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
DSEPARATION
61Processes of separation using semi-permeable membranes, e.g. dialysis, osmosis, ultrafiltration; Apparatus, accessories or auxiliary operations specially adapted therefor
24Dialysis ; ; Membrane extraction
28Apparatus therefor
B01D 2313/06
BPERFORMING OPERATIONS; TRANSPORTING
01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
DSEPARATION
2313Details relating to membrane modules or apparatus
06External membrane module supporting or fixing means
G01N 33/15
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
15Medicinal preparations ; ; Physical properties thereof, e.g. dissolubility
G01N 2013/006
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
13Investigating surface or boundary effects, e.g. wetting power; Investigating diffusion effects; Analysing materials by determining surface, boundary, or diffusion effects
006Dissolution of tablets or the like
Applicants PHARMA TEST APPBAU AG
Inventors WACKER MATTHIAS
JANAS CHRISTINE
Designated States
Title
(DE) DIALYSEZELLE FÜR EINE IN-VITRO-FREISETZUNGSTESTAPPARATUR, VERWENDUNG DER DIALYSEZELLE UND IN-VITRO-FREISETZUNGSTESTAPPARATUR
(EN) DIALYSIS CELL FOR AN IN-VITRO RELEASE TEST APPARATUS, USE OF THE DIALYSIS CELL AND IN-VITRO RELEASE TEST APPARATUS
(FR) CELLULE DE DIALYSE POUR UN APPAREIL DE TEST DE LIBÉRATION IN VITRO, UTILISATION DE LA CELLULE DE DIALYSE ET APPAREIL DE TEST DE LIBÉRATION IN VITRO
Abstract
(DE) Bei einer Dialysezelle für eine In-vitro-Freisetzungstestapparatur zum Ermitteln eines Freisetzungsverhaltens, wie einer Freisetzungsrate, einer Substanz einer Stoffzusammensetzung, wie eines Arzneimittels, welche Substanz an Molekularträger, wie Liposome, Mizellen oder Nanopartikel, gebunden ist, gegenüber einem Substanzaufnahmefluid mit einem Zelleninnenraum und einer den Zelleninnenraum zumindest teilweise begrenzende Dialysemembran, die die gebundene Substanz zurückhält, für in das Substanzaufnahmefluid freigesetzte Substanz durchlässig ist und für das Substanzaufnahmefluid zumindest teilweise durchlässig ist, ist vorgesehen, dass die Dialysemembran an einer Tragstruktur befestigt ist, die zur festen Montage der Dialysezelle an einer gegenüber der In-vitro-Freisetzungstestapparatur ortsfesten Montageposition ausgelegt ist.
(EN) The invention relates to a dialysis cell for an in-vitro release test apparatus for identifying a release behavior, such as a release rate, a substance of a material composition, such as a medication, said substance being bonded to molecular carriers such as liposomes, micelles or nanoparticles, relative to a substance absorption fluid having a cell interior and a dialysis membrane at least partially bordering the cell interior which retains the bound substance, is permeable for the substance released in the substance absorption fluid and is at least partially permeable for the substance absorption fluid, wherein the dialysis membrane is fastened to a support structure which is designed for permanent assembly of the dialysis cell at an assembly position which is stationary relative to the in-vitro release test apparatus.
(FR) Cellule de dialyse pour un appareil de test de libération in vitro servant à déterminer un comportement de libération, par exemple une vitesse de libération, d'une substance d'une composition de substances, par exemple un médicament, ladite substance étant liée à des excipients moléculaires, tels que des liposomes, micelles ou nanoparticules, vis-à-vis d'un fluide absorbant la substance. Cette cellule de dialyse comprend une chambre intérieure et une membrane de dialyse qui délimite au moins partiellement la chambre intérieure, retient la substance liée, est perméable vis-à-vis de la substance libérée dans le fluide absorbant la substance et au moins partiellement perméable vis-à-vis du fluide absorbant la substance. Selon l'invention, la membrane de dialyse est fixée à une structure de support qui est conçue pour le montage fixe de la cellule de dialyse dans une position de montage fixe par rapport à l'appareil de test de libération in vitro.
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