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1. EP2996719 - NOVEL VACCINE COMPOSITIONS COMPRISING IMMUNOSTIMULATORY OLIGONUCLEOTIDES

Office
European Patent Office
Application Number 14729191
Application Date 12.05.2014
Publication Number 2996719
Publication Date 23.03.2016
Publication Kind B1
IPC
A61K 39/39
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
39characterised by the immunostimulating additives, e.g. chemical adjuvants
A61K 39/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
A61K 39/008
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
002Protozoa antigens
008Leishmania antigens
A61K 39/12
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
12Viral antigens
A61K 39/27
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
12Viral antigens
245Herpetoviridae, e.g. herpes simplex virus
27Equine rhinopneumonitis virus
CPC
A61K 39/008
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
002Protozoa antigens
008Leishmania antigens
A61K 39/27
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
12Viral antigens
245Herpetoviridae, e.g. herpes simplex virus
27Equine rhinopneumonitis virus
A61K 39/39
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
39characterised by the immunostimulating additives, e.g. chemical adjuvants
A61K 2039/55561
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
555characterised by a specific combination antigen/adjuvant
55511Organic adjuvants
55561CpG containing adjuvants; Oligonucleotide containing adjuvants
A61K 2039/55577
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
555characterised by a specific combination antigen/adjuvant
55511Organic adjuvants
55577Saponins; Quil A; QS21; ISCOMS
C12N 2710/16034
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
2710dsDNA Viruses
00011dsDNA Viruses
16011Herpesviridae
16034Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
Applicants ZOETIS SERVICES LLC
Inventors DOMINOWSKI PAUL JOSEPH
RAI SHARATH K
SLY LAUREL MARY
COOK COREY PATRICK
MWANGI DUNCAN
FOSS DENNIS L
KREBS RICHARD LEE
Designated States
Priority Data 201361823189 14.05.2013 US
Title
(DE) NEUARTIGE IMPFSTOFFZUSAMMENSETZUNGEN MIT IMMUNSTIMULIERENDEN OLIGONUKLEOTIDEN
(EN) NOVEL VACCINE COMPOSITIONS COMPRISING IMMUNOSTIMULATORY OLIGONUCLEOTIDES
(FR) NOUVELLES COMPOSITIONS DE VACCIN COMPRENANT DES OLIGONUCLÉOTIDES IMMUNOSTIMULATEURS
Abstract
(EN) The invention provides a vaccine composition comprising an antigen component and an adjuvant component, wherein the adjuvant component comprises a P-class immunostimulatory oligonucleotide and either a combination of a saponin and a sterol; or an oily phase comprising an oil and, optionally, one or more emulsifiers, said oily phase comprising 2-20% v/v of the vaccine composition, wherein said antigen component is an EHV antigen or a Leishmania antigen.
(FR) La présente invention concerne une composition de vaccin comprenant une composante antigène et une composante adjuvant, la composant adjuvant comprenant un oligonucléotide immunostimulateur de classe P et soit une association de saponine et d'un stérol; soit une phase huileuse comprenant une huile et, facultativement, un ou plusieurs émulsifiants, ladite phase huileuse constituant 2 à 20 % v/v de la composition de vaccin, ladite composante antigène étant un antigène EHV ou un antigène Leishmania.