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1. (EP2994750) MICROFLUIDIC DEVICES AND METHODS FOR PERFORMING SERUM SEPARATION AND BLOOD CROSS-MATCHING

Office : European Patent Office
Application Number: 14794854 Application Date: 07.05.2014
Publication Number: 2994750 Publication Date: 16.03.2016
Publication Kind : A4
Designated States: AL, AT, BA, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LI, LT, LU, LV, MC, ME, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR
Prior PCT appl.: Application Number:US2014037192 ; Publication Number: Click to see the data
IPC:
G01N 33/80
B01L 3/00
G01N 33/49
G PHYSICS
01
MEASURING; TESTING
N
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33
Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48
Biological material, e.g. blood, urine; Haemocytometers
50
Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
80
involving blood groups or blood types
B PERFORMING OPERATIONS; TRANSPORTING
01
PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
L
CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
3
Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
G PHYSICS
01
MEASURING; TESTING
N
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33
Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48
Biological material, e.g. blood, urine; Haemocytometers
483
Physical analysis of biological material
487
of liquid biological material
49
blood
CPC:
G01N 33/80
B01L 3/502715
B01L 3/502723
B01L 3/50273
B01L 3/502738
B01L 3/502753
B01L 2200/027
B01L 2200/10
B01L 2300/0681
B01L 2300/0816
B01L 2300/0883
B01L 2400/0406
B01L 2400/0481
G01N 33/491
Applicants: MICRONICS INC
Inventors: KOLB ANDREW W
ELMUFDI CAROLINA L
BATTRELL C FREDERICK
Priority Data: 201361820576 07.05.2013 US
201361820579 07.05.2013 US
201361820585 07.05.2013 US
2014037192 07.05.2014 US
Title: (DE) MIKROFLUIDISCHE VORRICHTUNGEN UND VERFAHREN ZUR DURCHFÜHRUNG VON SERUMTRENNUNG UND BLUTKREUZPROBEN
(EN) MICROFLUIDIC DEVICES AND METHODS FOR PERFORMING SERUM SEPARATION AND BLOOD CROSS-MATCHING
(FR) DISPOSITIFS MICROFLUIDIQUES ET MÉTHODES DE SÉPARATION DU SÉRUM ET DE COMPATIBILITÉ CROISÉE DU SANG
Abstract:
(EN) Microfluidic cartridges or devices for serum separation and blood cross-match analysis are provided. The devices may include a serum separation subcircuit alone or in combination with a solute mixing subcircuit. The serum separation subcircuit promotes on-cartridge clotting of a blood sample and manipulates the flow of the separated serum sample for subsequent cross-match analysis with a second blood sample, for example. The solute mixing subcircuit includes at least two intake channels, one for a whole blood sample from, for example, a blood donor and the other for the separated serum sample from, for example, a transfusion recipient. The solute mixing subcircuit further includes a serpentine mixing channel conjoined to a downstream channel. Under vacuum generated by a conjoined finger pump, the two input streams fill the serpentine mixing and downstream channels due to capillary action, enabling visualization of an agglutination reaction.
(FR) L'invention concerne des cartouches ou dispositifs microfluidiques pour la séparation du sérum et l'analyse de compatibilité croisée du sang. Les dispositifs peuvent comprendre un sous-circuit de séparation du sérum seul ou en association avec un sous-circuit de mélange de soluté. Le sous-circuit de séparation du sérum favorise la coagulation sur la cartouche d'un échantillon de sang et manipule le flux de l'échantillon de sérum séparé pour l'analyse de compatibilité croisée du sang avec un second échantillon de sang, par exemple. Le sous-circuit de mélange de soluté comprend au moins deux canaux d'admission, un pour l'échantillon de sang total provenant, par exemple, d'un donneur de sang, et l'autre pour l'échantillon de sérum séparé provenant, par exemple, d'un receveur de transfusion. Le sous-circuit de mélange de soluté comprend par ailleurs un canal de mélange en zigzag joint à un canal en aval. Une pompe actionnée par le doigt génère du vide, les deux courants d'admission remplissent le canal de mélange en zigzag et le canal en aval par capillarité, ce qui permet d'observer la réaction d'agglutination.
Also published as:
US20160109467WO/2014/182844