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1. EP2988682 - KIT FOR PRODUCING A CROSS-LINKED GEL FOR SURROUNDING URINARY CALCULI AND/OR FRAGMENTS THEREOF

Office
European Patent Office
Application Number 13756036
Application Date 22.08.2013
Publication Number 2988682
Publication Date 02.03.2016
Publication Kind B1
IPC
A61B 17/22
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
BDIAGNOSIS; SURGERY; IDENTIFICATION
17Surgical instruments, devices or methods, e.g. tourniquets
22Implements for squeezing-off ulcers or the like on inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; for invasive removal or destruction of calculus using mechanical vibrations; for removing obstructions in blood vessels, not otherwise provided for
A61K 47/36
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
30Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
36Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
A61L 24/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES
24Surgical adhesives or cements; Adhesives for colostomy devices
A61L 24/04
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES
24Surgical adhesives or cements; Adhesives for colostomy devices
04containing macromolecular materials
CPC
A61B 17/22
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
BDIAGNOSIS; SURGERY; IDENTIFICATION
17Surgical instruments, devices or methods, e.g. tourniquets
22Implements for squeezing-off ulcers or the like on ; the inside of; inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; ; Apparatus for removing obstructions in blood vessels, not otherwise provided for
A61B 2017/00876
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
BDIAGNOSIS; SURGERY; IDENTIFICATION
17Surgical instruments, devices or methods, e.g. tourniquets
00831Material properties
00876magnetic
A61L 31/042
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES
31Materials for other surgical articles ; , e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
04Macromolecular materials
042Polysaccharides
A61L 31/14
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES
31Materials for other surgical articles ; , e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
14Materials characterised by their function or physical properties ; , e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
A61L 31/145
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES
31Materials for other surgical articles ; , e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
14Materials characterised by their function or physical properties ; , e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
145Hydrogels or hydrocolloids
A61L 2300/102
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES
2300Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
10containing or releasing inorganic materials
102Metals or metal compounds, e.g. salts such as bicarbonates, carbonates, oxides, zeolites, silicates
Applicants FRAUNHOFER-GESELLSCHAFT ZUR FÖRDERUNG DER ANGEWANDTEN FORSCHUNG E V
ALBERT-LUDWIGS-UNIVERSITÄT FREIBURG
Inventors GRUNWALD INGO
RICHTER KATHARINA
MIERNIK ARKADIUSZ
SCHOENTHALER MARTIN
Designated States
Title
(DE) KIT ZUM HERSTELLEN EINES VERNETZTEN GELS ZUM UMSCHLIESSEN VON HARNSTEINEN UND/ODER HARNSTEINFRAGMENTEN
(EN) KIT FOR PRODUCING A CROSS-LINKED GEL FOR SURROUNDING URINARY CALCULI AND/OR FRAGMENTS THEREOF
(FR) KIT DE FABRICATION D'UN GEL RÉTICULÉ POUR ENTOURER DES CALCULS URINAIRES ET/OU DES FRAGMENTS DE CALCULS URINAIRES
Abstract
(DE)
Beschrieben wird ein Kit zum Herstellen eines vernetzten Gels zum Umschließen von Harnsteinen und/oder Harnsteinfragmenten, insbesondere Nierensteinen und/oder Nierensteinfragmenten, umfassend eine Zusammensetzung (A), enthaltend ein oder mehrere kationisch vernetzbare Polymere, und eine Zusammensetzung (B), enthaltend ein oder mehrere Vernetzungsmittel zum Vernetzen des bzw. der kationisch vernetzbaren Polymere, wobei die Zusammensetzung (A) und/oder die Zusammensetzung (B) zudem magnetisierbare Teilchen enthält, oder das Kit zudem eine Zusammensetzung (C) umfasst, die magnetisierbare Teilchen enthält. Bei Kontakt der Zusammensetzung (A) mit der Zusammensetzung (B) in einem Bereich des Harntrakts, insbesondere der Niere, der Harnsteine und/oder Harnsteinfragmente, insbesondere Nierensteine und/oder Nierensteinfragmente, enthält, entsteht ein vernetztes Gel, das die Harnsteine und/oder Harnsteinfragmente, insbesondere Nierensteine und/oder Nierensteinfragmente, teilweise oder vollständig umschließt und das die magnetisierbaren Teilchen enthält. Unter Ausnutzung magnetischer Wechselwirkungen kann anschließend das Gel mitsamt den Harnsteinen und/oder Harnsteinfragmenten, insbesondere Nierensteinen und/oder Nierensteinfragmenten aus dem Körper entfernt werden.

(EN)
Described is a kit for producing a crosslinked gel for surrounding urinary calculi and/or fragments thereof, more particularly kidney stones and/or fragments thereof, comprising a composition (A) comprising one or more cationically crosslinkable polymers, and a composition (B) comprising one or more crosslinking agents for crosslinking the cationically crosslinkable polymer(s). The compositions (A) and/or (B) further comprise magnetizable particles, or the kit further comprises a composition (C) that comprises magnetizable particles. On contact between compositions (A) and (B) in a region of the urinary tract, more particularly the kidney, that contains urinary calculi and/or fragments thereof, more particularly kidney stones and/or fragments thereof, a crosslinked gel is formed that partly or fully surrounds the urinary calculi and/or fragments thereof, more particularly kidney stones and/or fragments thereof, and that comprises the magnetizable particles. The gel together with the urinary calculi and/or fragments thereof, more particularly kidney stones and/or fragments thereof, can then be removed from the body by using magnetic interactions.

(FR)
L'invention concerne un kit pour la production d'un gel réticulé pour entourer des calculs urinaires et/ou des fragments de calculs urinaires, en particulier des calculs rénaux et/ou des fragments de calculs rénaux, comprenant une composition (A), contenant un ou plusieurs polymères pouvant être réticulés au niveau cationique, et une composition (B), contenant un ou plusieurs agents de réticulation pour réticuler le ou les polymères pouvant être réticulés au niveau cationique. La composition (A) et/ou la composition (B) contient en outre des particules pouvant être aimantées, ou le kit comprend en outre une composition (C) qui contient des particules pouvant être aimantées. Lors du contact de la composition (A) avec la composition (B) dans une zone des voies urinaires, en particulier des reins, qui contient des calculs urinaires et/ou des fragments de calculs urinaires, en particulier des calculs rénaux et/ou des fragments de calculs rénaux, se forme un gel réticulé qui entoure partiellement ou complètement les calculs urinaires et/ou les fragments de calculs urinaires, en particulier les calculs rénaux et/ou les fragments de calculs rénaux, et qui contient les particules pouvant être aimantées. L'utilisation d'interactions magnétiques permet ensuite d'éliminer du corps le gel avec les calculs urinaires et/ou les fragments de calculs urinaires, en particulier les calculs rénaux et/ou les fragments de calculs rénaux.