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1. EP2986370 - METHOD FOR COMBINATORIAL PARTICLE MANIPULATION FOR PRODUCING HIGH-DENSITY MOLECULE ARRAYS, IN PARTICULAR PEPTIDE ARRAYS, AND MOLECULE ARRAYS THAT CAN BE OBTAINED BY MEANS THEREOF

Office
European Patent Office
Application Number 14724633
Application Date 17.04.2014
Publication Number 2986370
Publication Date 24.02.2016
Publication Kind B1
IPC
B01J 19/00
BPERFORMING OPERATIONS; TRANSPORTING
01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
19Chemical, physical or physico-chemical processes in general; Their relevant apparatus
C40B 50/18
CCHEMISTRY; METALLURGY
40COMBINATORIAL TECHNOLOGY
BCOMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES, IN SILICO LIBRARIES
50Methods of creating libraries, e.g. combinatorial synthesis
14Solid phase synthesis, i.e. wherein one or more library building blocks are bound to a solid support during library creation; Particular methods of cleavage from the solid support
18using a particular method of attachment to the solid support
CPC
B01J 19/0046
BPERFORMING OPERATIONS; TRANSPORTING
01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
19Chemical, physical or physico-chemical processes in general; Their relevant apparatus
0046Sequential or parallel reactions, e.g. for the synthesis of polypeptides or polynucleotides; Apparatus and devices for combinatorial chemistry or for making molecular arrays
B01J 2219/00317
BPERFORMING OPERATIONS; TRANSPORTING
01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
2219Chemical, physical or physico-chemical processes in general; Their relevant apparatus
00274Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
00277Apparatus
00279Features relating to reactor vessels
00306Reactor vessels in a multiple arrangement
00313the reactor vessels being formed by arrays of wells in blocks
00315Microtiter plates
00317Microwell devices, i.e. having large numbers of wells
B01J 2219/00441
BPERFORMING OPERATIONS; TRANSPORTING
01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
2219Chemical, physical or physico-chemical processes in general; Their relevant apparatus
00274Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
00277Apparatus
00351Means for dispensing and evacuation of reagents
00436Maskless processes
00441using lasers
B01J 2219/00466
BPERFORMING OPERATIONS; TRANSPORTING
01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
2219Chemical, physical or physico-chemical processes in general; Their relevant apparatus
00274Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
00277Apparatus
00457Dispensing or evacuation of the solid phase support
00459Beads
00466in a slurry
B01J 2219/00468
BPERFORMING OPERATIONS; TRANSPORTING
01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
2219Chemical, physical or physico-chemical processes in general; Their relevant apparatus
00274Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
00277Apparatus
00457Dispensing or evacuation of the solid phase support
00459Beads
00468by manipulation of individual beads
B01J 2219/00596
BPERFORMING OPERATIONS; TRANSPORTING
01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
2219Chemical, physical or physico-chemical processes in general; Their relevant apparatus
00274Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
00583Features relative to the processes being carried out
00596Solid-phase processes
Applicants KARLSRUHER INST TECHNOLOGIE
PEPPERPRINT GMBH
Inventors MÄRKLE FRIEDER
NESTEROV-MÜLLER ALEXANDER
BREITLING FRANK
LÖFFLER FELIX
SCHILLO SEBASTIAN
BYKOVSKAYA VALENTINA
VON BOJNICIC-KNINSKI CLEMENS
LEIBE KLAUS
Designated States
Priority Data 14724633 17.04.2014 EP
2013001141 17.04.2013 EP
Title
(DE) VERFAHREN ZUR KOMBINATORISCHEN PARTIKELMANIPULATION ZUR HERSTELLUNG VON HOCHDICHTEN MOLEKÜLARRAYS, INSBESONDERE VON PEPTIDARRAYS, UND DAMIT ERHÄLTLICHE MOLEKÜLARRAYS
(EN) METHOD FOR COMBINATORIAL PARTICLE MANIPULATION FOR PRODUCING HIGH-DENSITY MOLECULE ARRAYS, IN PARTICULAR PEPTIDE ARRAYS, AND MOLECULE ARRAYS THAT CAN BE OBTAINED BY MEANS THEREOF
(FR) PROCÉDÉ DE MANIPULATION DE PARTICULES COMBINATOIRE POUR PRODUIRE DES RÉSEAUX DE MOLÉCULES À HAUTE DENSITÉ, EN PARTICULIER DES RÉSEAUX DE PEPTIDES, ET RÉSEAUX DE MOLÉCULES POUVANT ÊTRE OBTENUS PAR CE PROCÉDÉ
Abstract
(DE)
Die vorliegende Erfindung betrifft ein Verfahren zur kombinatorischen Partikelmanipulation zur Herstellung von hochdichten Molekülarrays sowie die daraus erhaltenen hochdichten Molekülarrays. Insbesondere betrifft die vorliegende Erfindung ein Verfahren zur Herstellung von hochdichten Molekülarrays, insbesondere von Peptid- oder Oligonukleotidarrays, durch kombinatorische Strukturierung von Partikeln, wobei die Strukturierung durch selektive und direkte Einwirkung elektromagnetischer Strahlung erreicht wird.

(EN)
The present invention relates to a method for combinatorial particle manipulation for producing high-density molecule arrays and the high-density molecule arrays obtained therefrom. In particular, the present invention relates to a method for producing high-density molecule arrays, in particular peptide or oligonucleotide arrays, by means of the combinatorial structuring of particles, wherein the structuring is achieved by the selective and direct action of electromagnetic radiation.

(FR)
La présente invention concerne un procédé de manipulation de particules combinatoire pour produire des réseaux de molécules à haute densité, ainsi que les réseaux de molécules à haute densité obtenus par ce procédé. La présente invention concerne en particulier un procédé pour produire des réseaux de molécules à haute densité, en particulier des réseaux de peptides ou d'oligonucléotides, par structuration combinatoire de particules, la structuration étant obtenue par action sélective et directe d'un rayonnement électromagnétique.