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1. (EP2970970) ANTISENSE OLIGONUCLEOTIDES FOR TREATMENT OF CANCER STEM CELLS

Office : European Patent Office
Application Number: 14770117 Application Date: 14.03.2014
Publication Number: 2970970 Publication Date: 20.01.2016
Publication Kind : B1
Designated States: AL,AT,BA,BE,BG,CH,CY,CZ,DE,DK,EE,ES,FI,FR,GB,GR,HR,HU,IE,IS,IT,LI,LT,LU,LV,MC,ME,MK,MT,NL,NO,PL,PT,RO,RS,SE,SI,SK,SM,TR
Prior PCT appl.: Application Number:US2014029606 ; Publication Number: Click to see the data
IPC:
C12N 15/11
A61K 48/00
C12N 5/00
C12N 15/00
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15
Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09
Recombinant DNA-technology
11
DNA or RNA fragments; Modified forms thereof
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
48
Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
5
Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15
Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
CPC:
C12N 15/113
A61K 31/7088
A61K 31/7105
A61K 45/06
C12N 5/0693
C12N 2310/113
C12N 2320/30
C12N 2320/31
C12N 2501/65
C12N 2501/999
C12N 2510/00
Applicants: ANDES BIOTECHNOLOGIES GLOBAL INC
Inventors: BURZIO ERIZ LUIS O
BURZIO MENENDEZ VERONICA A
VILLEGAS OLAVARRIA JAIME E
Priority Data: 201361785269 14.03.2013 US
201361790072 15.03.2013 US
2014029606 14.03.2014 US
201461937438 07.02.2014 US
Title: (DE) ANTISENSE-OLIGONUKLEOTIDE ZUR BEHANDLUNG VON KREBSSTAMMZELLEN
(EN) ANTISENSE OLIGONUCLEOTIDES FOR TREATMENT OF CANCER STEM CELLS
(FR) OLIGONUCLÉOTIDES ANTISENS POUR LE TRAITEMENT DE CELLULES SOUCHES CANCÉREUSES
Abstract: front page image
(EN) The invention provides oligonucleotides complementary to a non-coding chimeric mitochondrial RNA as well as compositions and kits comprising the same, and their use in treating and preventing metastasis or relapse of a cancer in an individual previously treated for cancer with a therapy. The invention also provides oligonucleotides complementary to a non-coding chimeric mitochondrial RNA as well as compositions and kits comprising the same, and their use in treating a refractory cancer (e.g., a refractory HPV-associated cancer).
(FR) L'invention concerne des oligonucléotides complémentaires à un ARN mitochondrial chimérique non codant, ainsi que des compositions et des trousses comprenant ceux-ci, et leur utilisation dans le traitement et la prévention d'une métastase ou d'une récidive d'un cancer chez un individu traité auparavant pour le cancer par une thérapie. L'invention concerne également des oligonucléotides complémentaires à un ARN mitochondrial chimérique non codant, ainsi que des compositions et des trousses comprenant ceux-ci, et leur utilisation dans le traitement d'un cancer réfractaire (par exemple un cancer réfractaire associé à HPV).
Also published as:
CA2906198CN105229150US20160138015BR112015022308ES2708650WO/2014/153209