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1. EP1992638 - IMMUNOMODULATORY AND ANTI-TUMOUR PEPTIDES

Office
European Patent Office
Application Number 07711100
Application Date 23.02.2007
Publication Number 1992638
Publication Date 19.11.2008
Publication Kind B1
IPC
C07K 14/435
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435from animals; from humans
A61K 38/17
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
17from animals; from humans
CPC
A61K 38/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
A61P 35/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35Antineoplastic agents
A61P 35/04
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35Antineoplastic agents
04specific for metastasis
A61P 37/04
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
37Drugs for immunological or allergic disorders
02Immunomodulators
04Immunostimulants
C07K 14/43509
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435from animals; from humans
43504from invertebrates
43509from crustaceans
Applicants CT INGENIERIA GENETICA BIOTECH
Inventors GUERRA VALLESPI MARIBEL
TORRENS MADRAZO ISIS DEL CARMEN
REYES ACOSTA OSVALDO
GARAY PEREZ HILDA ELISA
GUILLEN NIETO GERARDO ENRIQUE
ACEVEDO CASTRO BORIS ERNESTO
UBIETA GOMEZ RAIMUNDO
Designated States
Priority Data 20060047 24.02.2006 CU
Title
(DE) IMMUNMODULATORISCHE UND GEGEN TUMORE WIRKENDE PEPTIDE
(EN) IMMUNOMODULATORY AND ANTI-TUMOUR PEPTIDES
(FR) PEPTIDES AVANT UNE PROPRIETE ANTI-TUMORALE ET IMMUNOMODULATRICE
Abstract
(EN)
The present invention is related to the development of peptides derived from the sequence HYRIKPTFRRLKWKKYKGKFW, showing aminoacids substitutions, these peptides unable to bind to the lipopolysaccharide and bearing anti-tumoral and immunomodulatory capacities. These peptides alone or in combination are useful to treat cancer, and also in synergy with conventional therapies.

(FR)
L'invention porte sur le développement de peptides issus de la séquence HYRIKPTFRRLKWKKYKGKFW, et dans laquelle on a introduit des substitutions d'acides aminés, qui assurent la dissociation de la capacité de liaison au lipopolysaccharide, et qui potentialisent l'effet anti-tumoral et immunomodulateur. Lesdits peptides et leurs combinaisons peuvent être utilisés dans le traitement du cancer, ainsi qu'en synergie avec les thérapies classiques.