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1. EP1953549 - ASBESTOS DETECTION METHOD and ASBESTOS DETECTION AGENT

Office
European Patent Office
Application Number 06823183
Application Date 08.11.2006
Publication Number 1953549
Publication Date 06.08.2008
Publication Kind B1
IPC
G01N 33/53
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48Biological material, e.g. blood, urine; Haemocytometers
50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
53Immunoassay; Biospecific binding assay; Materials therefor
G01N 33/566
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48Biological material, e.g. blood, urine; Haemocytometers
50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
53Immunoassay; Biospecific binding assay; Materials therefor
566using specific carrier or receptor proteins as ligand binding reagent
CPC
G01N 33/5308
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
48Biological material, e.g. blood, urine
50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
53Immunoassay; Biospecific binding assay; Materials therefor
5308for analytes not provided for elsewhere, e.g. nucleic acids, uric acid, worms, mites
G01N 2500/02
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
2500Screening for compounds of potential therapeutic value
02Screening involving studying the effect of compounds C on the interaction between interacting molecules A and B (e.g. A = enzyme and B = substrate for A, or A = receptor and B = ligand for the receptor)
Applicants UNIV HIROSHIMA NAT UNIV CORP
Inventors KURODA AKIO
NOMURA KAZUTAKA
Designated States
Priority Data 2005326502 10.11.2005 JP
2006005061 12.01.2006 JP
2006135674 15.05.2006 JP
2006203983 26.07.2006 JP
Title
(DE) ASBESTNACHWEISVERFAHREN und ASBESTNACHWEISMITTEL
(EN) ASBESTOS DETECTION METHOD and ASBESTOS DETECTION AGENT
(FR) PROCEDE DE DETECTION DE L'AMIANTE et AGENT DE DETECTION DE L'AMIANTE
Abstract
(EN) The present invention provides a prompt and easy asbestos detection method and a method for screening a candidate for an agent aiming at preventing or treating a disease for which asbestos is a causative or worsening factor. It is possible to quickly and easily detect asbestos in a sample by finding a protein capable of binding specifically to asbestos, allowing the protein or a fusion protein of the protein and a reporter protein to bind to asbestos in the sample, and then detecting the protein or the fusion protein having been bound to asbestos. A substance inhibiting the binding of actin to asbestos, which has been found out as a protein capable of binding specifically to asbestos, is a candidate for an agent aiming at preventing or treating a disease for which asbestos is a causative or worsening factor.
(FR) L'invention concerne un procédé permettant de détecter rapidement et sans inconvénient la présence d'amiante, ainsi qu'un procédé de criblage d'un agent candidat pour la mise au point d'un médicament destiné à la prévention ou au traitement de maladies causées ou aggravées par l'amiante. Ce procédé permet de détecter rapidement et sans inconvénient la présence d'amiante dans un échantillon. Il consiste à trouver une protéine capable de se fixer de manière spécifique sur l'amiante, à permettre à cette protéine ou à une protéine hybride composée de cette protéine et d'une protéine rapporteuse de se fixer sur l'amiante dans l'échantillon, puis à détecter la protéine ou la protéine hybride qui s'est fixée sur l'amiante. L'invention concerne également une substance qui inhibe la fixation de l'actine sur l'amiante. Il s'est avéré que cette substance agit comme une protéine capable de se fixer de manière spécifique sur l'amiante. Ainsi, cette substance constitue un agent candidat pour la mise au point d'un médicament destiné à la prévention ou au traitement de maladies causées ou aggravées par l'amiante.