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1. EP1912641 - METHODS AND COMPOSITIONS CONTAINING NATURAL FOLATES FOR PROTECTING AGAINST RADIATION DAMAGE

Office European Patent Office
Application Number 06773822
Application Date 21.06.2006
Publication Number 1912641
Publication Date 23.04.2008
Publication Kind B1
IPC
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
41
having five-membered rings with two or more ring hetero atoms, at least one of which is nitrogen, e.g. tetrazole
415
1,2-Diazoles
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
17
Drugs for dermatological disorders
16
Emollients or protectives, e.g. against radiation
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
39
General protective or antinoxious agents
A61K 31/415
A61P 17/16
A61P 39/00
CPC
A61K 31/415
A23L 33/15
A61K 8/4953
A61Q 17/04
Applicants SOUTH ALABAMA MEDICAL SCIENCE FOUND
CHILDRENS HOSPITAL & RES CENTER AT OAKLAND
Inventors BAILEY STEVEN W
AYLING JUNE E
OFFER TAL
LENTON KEVIN J
Designated States
Priority Data 2006024415 21.06.2006 US
69240105 21.06.2005 US
Title
(DE) VERFAHREN UND ZUSAMMENSETZUNGEN MIT NATÜRLICHEN FOLATEN ZUM SCHUTZ VOR STRAHLENSCHÄDEN
(EN) METHODS AND COMPOSITIONS CONTAINING NATURAL FOLATES FOR PROTECTING AGAINST RADIATION DAMAGE
(FR) METHODES ET COMPOSITIONS CONTENANT DES FOLATES NATURELS POUR PROTECTION CONTRE LES RADIOLESIONS
Abstract
(EN)
Disclosed are methods for protecting a subject from harmful effects of ionizing radiation. The method includes administering to the subject an effective amount of at least one reduced folate. Also disclosed are radioprotective compositions that include a first radioprotective agent and a second radioprotective agent, where the first radioprotective agent is a reduced folate. Methods for protecting a subject from harmful effects of ultraviolet radiation are also disclosed.

(FR)
L'invention concerne des méthodes destinées à protéger un sujet contre les effets nuisibles d'un rayonnement ionisant. Cette méthode consiste à administrer à ce sujet une dose efficace d'au moins un folate réduit. L'invention concerne également des compositions radioprotectrices renfermant un premier agent radioprotecteur et un second agent radioprotecteur, le premier agent radioprotecteur étant un folate réduit. L'invention se rapporte en outre à des méthodes destinées à protéger un sujet contre les effets nuisibles d'un rayonnement ultraviolet.