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1. EP1910345 - SUBSTITUTED AMIDES, THEIR PREPARATION AND THEIR USE AS PHARMACEUTICALS

Office European Patent Office
Application Number 06764178
Application Date 17.07.2006
Publication Number 1910345
Publication Date 16.04.2008
Publication Kind A1
IPC
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
409
Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
14
containing three or more hetero rings
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
55
having seven-membered rings, e.g. azelastine, pentylenetetrazole
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
7
Drugs for disorders of the blood or the extracellular fluid
02
Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
513
Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/, C07D477/232
02
in which the condensed system contains two hetero rings
04
Ortho-condensed systems
C07D 409/14
A61K 31/55
A61P 7/02
C07D 513/04
CPC
C07D 513/04
C07D 409/14
Applicants BOEHRINGER INGELHEIM INT
BOEHRINGER INGELHEIM PHARMA
Inventors GERLACH KAI
PRIEPKE HENNING
PFAU ROLAND
WIENEN WOLFGANG
SCHULER-METZ ANNETTE
DAHMANN GEORG
Designated States
Priority Data 05015588 19.07.2005 EP
06764178 17.07.2006 EP
06764178 17.07.2006 EP
Title
(DE) SUBSTITUIERTE AMIDE, DEREN HERSTELLUNG UND DEREN VERWENDUNG ALS ARZNEIMITTEL
(EN) SUBSTITUTED AMIDES, THEIR PREPARATION AND THEIR USE AS PHARMACEUTICALS
(FR) AMIDES SUBSTITUES, LEUR PREPARATION ET LEUR UTILISATION EN TANT QUE MEDICAMENT
Abstract
(DE)
Gegenstand der vorliegenden Erfindung sind neue substituierte Amide der allgemeinen Formel (I), in denen D, L, M, W und B wie in der Beschreibung definiert sind, deren Tautomere, deren Enantiomere, deren Diastereomere, deren Gemische und deren Salze, insbesondere deren physiologisch verträgliche Salze mit anorganischen oder organischen Säuren oder Basen, welche wertvolle Eigenschaften aufweisen. Die Verbindungen wirken als Inhibitoren des Faktor Xa.

(EN)
The present invention provides new substituted amides of the general formula (I) in which D, L, M, W and B are as defined in the description, their tautomers, their enantiomers, their diastereomers, mixtures thereof and salts thereof, particularly their physiologically acceptable salts with organic or inorganic acids or bases, which have valuable properties. The compounds act as inhibitors of factor Xa.

(FR)
Nouveaux amides substitués de formule générale (I) dans laquelle D, L, M, W et B sont tels que définis dans la description, leurs tautomères, leurs énantiomères, leurs diastéréomères, leurs mélanges et leurs sels, en particulier leurs sels acceptables sur le plan physiologique avec des acides ou des bases inorganiques ou organiques, qui possèdent des propriétés précieuses. Ces composés ont une action d'inhibition du facteur Xa.