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1. EP1904448 - PURIFICATION OF MONTELUKAST

Office European Patent Office
Application Number 06786369
Application Date 05.07.2006
Publication Number 1904448
Publication Date 02.04.2008
Publication Kind B1
IPC
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
215
Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
02
having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
16
with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
18
Halogen atoms or nitro radicals
C07D 215/18
CPC
C07D 215/18
Applicants TEVA PHARMA
Inventors STERIMBAUM GRETA
SHAPIRO EVGENY
CHEN KOBI
Designated States
Priority Data 2006026192 05.07.2006 US
69700005 05.07.2005 US
Title
(DE) REINIGUNG VON MONTELUKAST
(EN) PURIFICATION OF MONTELUKAST
(FR) PURIFICATION DU MONT√ČLUKAST
Abstract
(EN)
The present invention provides methods of purifying montelukast, a new isolated impurity of montelukast of formula I, method for its isolation, and method of using montelukast impurity as a reference marker and a reference standard.

(FR)
La présente invention concerne des méthodes de purification du montélukast, une nouvelle impureté isolée dans le montélukast de formule I, une méthode d'isolement de ladite impureté, et une méthode d’emploi de l'impureté du montélukast au titre de marqueur de référence et d'étalon de référence.