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1. EP1901724 - PERCUTANEOUSLY ABSORPTIVE OPHTHALMIC PREPARATION COMPRISING EPINASTINE

Office European Patent Office
Application Number 06781080
Application Date 07.07.2006
Publication Number 1901724
Publication Date 26.03.2008
Publication Kind A1
IPC
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9
Medicinal preparations characterised by special physical form
70
Web, sheet or filament bases
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9
Medicinal preparations characterised by special physical form
06
Ointments; Bases therefor
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9
Medicinal preparations characterised by special physical form
10
Dispersions; Emulsions
107
Emulsions
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
27
Drugs for disorders of the senses
02
Ophthalmic agents
14
Decongestants or antiallergics
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
37
Drugs for immunological or allergic disorders
08
Antiallergic agents
A61K 9/70
A61K 9/06
A61K 9/107
A61P 27/14
A61P 37/08
CPC
A61K 9/7023
A61K 9/0048
A61K 9/06
A61K 9/107
Applicants SENJU PHARMA CO
Inventors ISOWAKI AKIHARU
NAKAJIMA TOMOKO
OHTORI AKIRA
Designated States
Priority Data 2006314005 07.07.2006 JP
69736905 08.07.2005 US
Title
(DE) PERKUTAN RESORBIERBARE OPHTHALMISCHE ZUBEREITUNG MIT EPINASTIN
(EN) PERCUTANEOUSLY ABSORPTIVE OPHTHALMIC PREPARATION COMPRISING EPINASTINE
(FR) PRÉPARATION OPHTALMIQUE À ABSORPTION PERCUTANÉE COMPRENANT DE L'ÉPINASTINE
Abstract
(EN)
The present invention provides a percutaneously absorptive preparation for preventing or treating allergic eye disease, which comprises epinastine or a salt thereof as an active ingredient. In addition, the present invention provides a method for preventing or treating allergic eye disease, which comprises applying a percutaneously absorptive preparation comprising epinastine or a salt thereof to the skin surface including the skin surface of an eyelid, thereby causing transfer of a therapeutically effective amount of epinastine or a salt thereof from the preparation to an anterior ocular segment through the skin of the eyelid rather than a systemic blood flow. The present preparation can exert a pharmacological effect over a prolonged period by a single application, as compared to conventional preparations such as eye drops.

(FR)
La présente invention concerne une préparation à absorption percutanée pour la prévention ou le traitement d'une pathologie oculaire allergique, qui comprend de l'épinastine ou un sel de celle-ci comme principe actif. De plus, la présente invention concerne un procédé pour la prévention ou le traitement d'une telle pathologie qui comprend l'application d'une préparation à absorption percutanée comprenant de l'épinastine ou un sel de celle-ci sur la surface de la peau, y compris la surface de la peau d'une paupière, provoquant ainsi le transfert d'une quantité thérapeutiquement efficace d' épinastine ou d'un sel de celle-ci provenant de la préparation vers un segment oculaire antérieur par l'intermédiaire de la peau de la paupière plutôt que par le flux sanguin systémique. La présente préparation peut exercer un effet pharmacologique pendant une période prolongée par une seule application, comparée à des préparations conventionnelles telles que des collyres.