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1. (EP1907399) 5,6-DI-SUBSTITUTED OXADIAZOLOPYRAZINES AND THIADIAZOLOPYRAZINES AS CXC-CHEMOKINE RECEPTOR LIGANDS

Office : European Patent Office
Application Number: 06785619 Application Date: 27.06.2006
Publication Number: 1907399 Publication Date: 09.04.2008
Publication Kind : B1
Prior PCT appl.: Application Number:US2006024908 ; Publication Number: Click to see the data
IPC:
C07D 498/04
A61K 31/41
A61P 11/06
A61P 29/00
A61P 35/00
C07D 513/04
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
498
Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
02
in which the condensed system contains two hetero rings
04
Ortho-condensed systems
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
41
having five-membered rings with two or more ring hetero atoms, at least one of which is nitrogen, e.g. tetrazole
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
11
Drugs for disorders of the respiratory system
06
Antiasthmatics
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
29
Non-central analgesic, antipyretic or antiinflammatory agents, e.g antirheumatic agents; Non-steroidal antiinflammatory drugs (NSAIDs)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35
Antineoplastic agents
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
513
Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/, C07D477/232
02
in which the condensed system contains two hetero rings
04
Ortho-condensed systems
CPC:
C07D 513/04
C07F 9/6561
Applicants: SCHERING CORP
Inventors: PURAKKATTLE BIJU J
Priority Data: 2006024908 27.06.2006 US
69516205 29.06.2005 US
Title: (DE) 5,6-DISUBSTITUIERTE OXADIAZOLOPYRAZINE UND THIADIAZOLOPYRAZINE ALS LIGANDEN DES CXC-CHEMOKINREZEPTORS
(EN) 5,6-DI-SUBSTITUTED OXADIAZOLOPYRAZINES AND THIADIAZOLOPYRAZINES AS CXC-CHEMOKINE RECEPTOR LIGANDS
(FR) OXADIAZOLOPYRAZINES 5,6-DI-SUBSTITUÉES ET THIADIAZOLOPYRAZINES COMME LIGANDS RÉCEPTEURS DE CXC-CHIMIOKINE
Abstract:
(EN) Disclosed are compounds of the formula Chemical formula should be inserted here as it appears on the abstract in paper form. and the pharmaceutically acceptable salts thereof. The compounds are useful for the treatment of chemokine-mediated diseases such as COPD.
(FR) La présente invention concerne des composés de la formule (formule chimique à insérer ici) telle qu’indiquée dans l’abrégé sous forme papier et les sels pharmaceutiquement acceptables de ceux-ci. Les composés sont utilisés pour le traitement de maladies médiées par la chimiokine, telles que la broncho-pneumopathie chronique obstructive.
Also published as:
MXMX/a/2008/000367JP2009500328ES2353401CN101253180CA2613428WO/2007/005403