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1. (EP1906983) CYNARA SCOLYMUS EXTRACTS, THE USE THEREOF ANS FORMULATIONS CONTAINING THEM

Office : European Patent Office
Application Number: 06754391 Application Date: 16.06.2006
Publication Number: 1906983 Publication Date: 09.04.2008
Publication Kind : A2
Designated States: AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LI, LT, LU, LV, MC, NL, PL, PT, RO, SE, SI, SK, TR
Prior PCT appl.: Application Number:EP2006005778 ; Publication Number: Click to see the data
IPC:
A61K 36/28
A61P 1/00
A61P 3/06
A61P 9/10
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
36
Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
18
Magnoliophyta (angiosperms)
185
Magnoliopsida (dicotyledons)
28
Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
1
Drugs for disorders of the alimentary tract or the digestive system
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
3
Drugs for disorders of the metabolism
06
Antihyperlipidemics
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
9
Drugs for disorders of the cardiovascular system
10
for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
CPC:
A61K 36/28
A61K 36/185
A61K 36/55
Applicants: INDENA SPA
Inventors: BOMBARDELLI EZIO
FONTANA GABRIELE
GIORI ANDREA
MORAZZONI PAOLO
RONCHI MASSIMO
ARPINI SABRINA
Priority Data: 06754391 16.06.2006 EP
MI20051347 14.07.2005 IT
Title: (DE) CYNARA-SCOLYMUS-EXTRAKTE, IHRE VERWENDUNG UND SIE ENTHALTENDE FORMULIERUNGEN
(EN) CYNARA SCOLYMUS EXTRACTS, THE USE THEREOF ANS FORMULATIONS CONTAINING THEM
(FR) EXTRAITS DE CYNARA SCOLYMUS, LEUR UTILISATION ET FORMULATIONS LES CONTENANT
Abstract:
(EN) The present invention relates to the preparation of a Cynara scolymus extract obtainable by fractioning on a resin. The process of the invention allows to obtain an extract, starting from the aerial parts of the plant Cynara scolymus, containing three classes of active principles, namely dicaffeoylquinic acids, luteolin and cynaropicrin glycosides, in a constant ratio. Cynaropicrin is stabilized by addition of precise amounts of sulfated amino acids or suitable thio-derivatives. These extracts have hypolipemizing, anti-dyspeptic and vascular anti-inflammatory activities. The extracts are mainly formulated in Enothera biennis oil or in oils rich in &ohgr;-3 and &ohgr;-6 acids which enhance the vascular activity.
(FR) La présente invention concerne la préparation d'un extrait de Cynara scolymus pouvant être obtenu par fractionnement sur une résine. Le procédé de l'invention permet d'obtenir un extrait, à partir des parties aériennes de la plante Cynara scolymus, contenant trois classes de principes actifs, à savoir des acides dicafféoylquiniques, des glycosides de lutéoline et de cynaropicrine, dans un rapport constant. La cynaropicrine est stabilisée par addition de quantités précises d'acides aminés sulfatés ou de thio-dérivés appropriés. Ces extraits ont des activités vasculaires hypolipémiantes, antidyspeptiques et anti-inflammatoires. Les extraits sont principalement formulés dans l'huile d'Oenothera biennis ou dans des huiles riches en acides &ohgr;-3 et &ohgr;-6 qui améliorent l'activité vasculaire.
Also published as:
NO20080198NZ565025KR1020080038127JP2009501708US20090285911CN101222931
CA2614796AU2006269035IN160/KOLNP/2008WO/2007/006391