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1. EP1853728 - METHOD FOR PROGNOSIS OF A RESPONSE TO AN INFLIXIMAB TREATMENT OF PATIENTS SUFFERING FROM RHEUMATOID ARTHRITIS

Office European Patent Office
Application Number 06726199
Application Date 28.02.2006
Publication Number 1853728
Publication Date 14.11.2007
Publication Kind A1
IPC
C12Q 1/68
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
68involving nucleic acids
CPC
C12Q 1/6883
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS
1Measuring or testing processes involving enzymes, nucleic acids or microorganisms
68involving nucleic acids
6876Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
6883for diseases caused by alterations of genetic material
C12Q 2600/106
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS
2600Oligonucleotides characterized by their use
106Pharmacogenomics, i.e. genetic variability in individual responses to drugs and drug metabolism
C12Q 2600/158
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS
2600Oligonucleotides characterized by their use
158Expression markers
Applicants BIOMERIEUX SA
HOSPICES CIVILS DE LYON
Inventors TOH MYEW-LING
MIOSSEC PIERRE
BLOND JEAN-LUC
MOUGIN BRUNO
Designated States
Priority Data 0550540 01.03.2005 FR
2006050175 28.02.2006 FR
Title
(DE) VERFAHREN ZUR VORHERSAGE DER ANTWORT AUF EINE INFLIXIMAB-BEHANDLUNG VON PATIENTEN MIT RHEUMATOIDER ARTHRITIS
(EN) METHOD FOR PROGNOSIS OF A RESPONSE TO AN INFLIXIMAB TREATMENT OF PATIENTS SUFFERING FROM RHEUMATOID ARTHRITIS
(FR) PROCEDE POUR LE PRONOSTIC D'UNE REPONSE A UN TRAITEMENT PAR L' INFLIXIMAB DES PATIENTS ATTEINTS DE POLYARTHRITE RHUMATOIDE
Abstract
(EN)
The invention concerns an in vitro method for determining, from a biological sample, the response of a patient suffering from rheumatoid arthritis to a treatment directed against a cytokine involved in the inflammatory process of the disease characterized in that it consists in measuring the expression of the gene encoding synoviolin.

(FR)
La présente invention concerne un procédé in vitro pour déterminer, à partir d'un échantillon biologique, la réponse d'un patient atteint d'une polyarthrite rhumatoïde à un traitement dirigé contre une cytokine impliquée dans le processus inflammatoire de la maladie caractérisé en ce qu'on mesure l'expression du gène codant la synovioline.