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1. EP1812001 - NICOTINIC-OPIOID SYNERGY FOR ANALGESIA

Office
European Patent Office
Application Number 05811972
Application Date 20.10.2005
Publication Number 1812001
Publication Date 01.08.2007
Publication Kind A2
IPC
A61K 31/44
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
435having six-membered rings with one nitrogen as the only ring hetero atom
44Non-condensed pyridines; Hydrogenated derivatives thereof
A61K 31/435
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
435having six-membered rings with one nitrogen as the only ring hetero atom
CPC
A61K 31/14
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
13Amines
14Quaternary ammonium compounds, e.g. edrophonium, choline
A61K 31/22
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
21Esters, e.g. nitroglycerine, selenocyanates
215of carboxylic acids
22of acyclic acids, e.g. pravastatin
A61K 31/4439
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
435having six-membered rings with one nitrogen as the only ring hetero atom
44Non condensed pyridines; Hydrogenated derivatives thereof
4427containing further heterocyclic ring systems
4439containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
A61K 31/445
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
435having six-membered rings with one nitrogen as the only ring hetero atom
44Non condensed pyridines; Hydrogenated derivatives thereof
445Non condensed piperidines, e.g. piperocaine
A61K 31/485
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
435having six-membered rings with one nitrogen as the only ring hetero atom
47Quinolines; Isoquinolines
485Morphinan derivatives, e.g. morphine, codeine
A61K 45/06
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
45Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
Applicants UNIV COLUMBIA
Inventors SHAFER STEVEN
FLOOD PAMELA
Designated States
Priority Data 62083604 21.10.2004 US
Title
(DE) NIKOTINSÄURE-OPIOID-SYNERGIE ZUR ANALGESIE
(EN) NICOTINIC-OPIOID SYNERGY FOR ANALGESIA
(FR) SYNERGIE ENTRE NICOTINE ET OPIOIDES A DES FINS D'ANALGESIE
Abstract
(EN) This invention provides two methods for reducing, or inhibiting the onset of, pain in a subject. The first method for reducing, or inhibiting the onset of, pain in a subject comprises administering to the subject (a) a nicotinic receptor agonist, and (b) an opioid receptor agonist; wherein the ratio of nicotinic receptor agonist to opioid receptor agonist administered to the subject is less than 3:4 and greater than 1:100. The second method for reducing, or inhibiting the onset of, pain in a subject comprises administering to the subject (a) a nicotinic receptor agonist at a rate of less than 3 mg per three hour period; and (b) an opioid receptor agonist at a rate of less than 4 mg per three hour period. This invention also provides two compositions, a transdermal patch, and an article of manufacture for practicing the instant methods.
(FR) Cette invention concerne deux procédés servant à réduire la douleur chez un sujet ou à en empêcher l'apparition. Ce premier procédé destiné à réduire la douleur chez un sujet ou à en empêcher l'apparition consiste à administrer au sujet: (a) un agoniste de récepteur nicotinique, et (b) un agoniste de récepteur d'opioïdes; le rapport entre l'agoniste de récepteur nicotinique et l'agoniste de récepteur d'opioïdes administrés au sujet étant inférieur à 3/4 et supérieur à 1/100. Le second procédé destiné à réduire la douleur chez un sujet et/ou à en empêcher l'apparition consiste à administrer au sujet: (a) un agoniste de récepteur nicotinique à une dose inférieure à 3 mg par période de 3 heures; et (b) un agoniste de récepteur d'opioïdes à une dose inférieure à 4 mg par période de 3 heures. Cette invention concerne également deux compositions, un tampon transdermique et un article manufacturé de réalisation de ces procédés.
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