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1. EP1558760 - CRH RESPONSIVE GENES IN CNS

Office
European Patent Office
Application Number 03758054
Application Date 23.10.2003
Publication Number 1558760
Publication Date 03.08.2005
Publication Kind B1
IPC
C12Q 1/68
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
68involving nucleic acids
C07K 14/47
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435from animals; from humans
46from vertebrates
47from mammals
C07K 14/575
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435from animals; from humans
575Hormones
CPC
A61P 25/24
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25Drugs for disorders of the nervous system
24Antidepressants
C07K 14/47
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435from animals; from humans
46from vertebrates
47from mammals
C12Q 1/6883
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS
1Measuring or testing processes involving enzymes, nucleic acids or microorganisms
68involving nucleic acids
6876Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
6883for diseases caused by alterations of genetic material
C12Q 2600/158
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS
2600Oligonucleotides characterized by their use
158Expression markers
Applicants JANSSEN PHARMACEUTICA NV
Inventors PEETERS PIETER JOHAN
GOEHLMANN HINRICH W H
SWAGEMAKERS SIGRID MARIA ALICE
KASS STEFAN ULRICH
STECKLER THOMAS H W
FIERENS FREDERIK L P
Designated States
Priority Data 0212274 31.10.2002 EP
03758054 23.10.2003 EP
Title
(DE) GENE DES ZNS, DIE AUF CRH REAGIEREN
(EN) CRH RESPONSIVE GENES IN CNS
(FR) GENES REAGISSANT A L'HORMONE LIBERATRICE DE LA CORTICOTROPINE DANS LE SYSTEME NERVEUX CENTRAL
Abstract
(EN)
The present invention relates generally to therapy and diagnosis of depression. In particular this invention relates to the polypeptides as well as to the polynucleotides encoding these polypeptides, wherein said polypeptides are shown to play a central role in mediating the endocrine response to corticotropin releasing hormone. These polypeptides and polynucleotides are useful in the diagnosis, treatment and/or prevention of depression.

(FR)
Cette invention, qui a trait, d'une manière générale, à une méthode thérapeutique et diagnostique de la dépression, concerne, plus précisément, des polypeptides ainsi que des polynucléotides codant ces polypeptides, lesquels polypeptides jouent un rôle éminent, s'agissant de médiatiser une réaction endocrine à l'égard de l'hormone libératrice de la corticotropine. Ces polynucléotides et ces polypeptides se révèlent des plus utiles en matière de diagnostic, de traitement et/ou de prévention de la dépression.