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1. EP1294747 - SYNTHETIC METHODS FOR APLIDINE AND NEW ANTITUMORAL DERIVATIVES, METHODS OF MAKING AND USING THEM

Office
European Patent Office
Application Number 01945484
Application Date 02.07.2001
Publication Number 1294747
Publication Date 26.03.2003
Publication Kind B1
IPC
A61K 38/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
A61K 38/04
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
04Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
C07K 11/00
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
11Depsipeptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
A61P 35/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35Antineoplastic agents
C07C 271/22
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
271Derivatives of carbamic acid, i.e. compounds containing any of the groups the nitrogen atom not being part of nitro or nitroso groups
06Esters of carbamic acids
08having oxygen atoms of carbamate groups bound to acyclic carbon atoms
10with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
22to carbon atoms of hydrocarbon radicals substituted by carboxyl groups
C07K 1/06
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
1General processes for the preparation of peptides
06using protecting groups or activating agents
CPC
A61K 38/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
C07K 5/0205
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
5Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
02containing at least one abnormal peptide link
0205containing the structure -NH-(X)3-C(=0)-, e.g. statine or derivatives thereof
C07K 5/0808
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
5Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
04containing only normal peptide links
08Tripeptides
0802with the first amino acid being neutral
0804and aliphatic
0808the side chain containing 2 to 4 carbon atoms, e.g. Val, Ile, Leu
C07K 7/02
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
7Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
02Linear peptides containing at least one abnormal peptide link
A61P 35/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35Antineoplastic agents
C07K 11/00
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
11Depsipeptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
Applicants PHARMA MAR SA
Inventors RODRIGUEZ IGNACIO
POLANCO CONCEPCI N
CUEVAS FELIX
MENDEZ PALOMA
CUEVAS CARMEN
GALLEGO PILAR
MUNT SIMON
MANZANARES IGNACIO
GARCIA LOPEZ MARIA TERESA
GUTIERREZ RODRIGUEZ MARTA
HERRANZ HERRANZ ROSARIO
Designated States
Priority Data 0016148 30.06.2000 GB
0102901 02.07.2001 GB
0103750 15.02.2001 GB
Title
(DE) VERFAHREN ZUR HERSTELLUNG VON APLIDIN UND NEUE ANTITUMORALEN DERIVATE, VERFAHREN ZU DEREN HERSTELLUNG UND ZU DEREN VERWENDUNG
(EN) SYNTHETIC METHODS FOR APLIDINE AND NEW ANTITUMORAL DERIVATIVES, METHODS OF MAKING AND USING THEM
(FR) PROCEDES DE SYNTHESE POUR L'APLIDINE ET DE NOUVEAUX DERIVES ANTITUMORAUX, LEUR PROCEDE DE PRODUCTION ET D'UTILISATION
Abstract
(EN) The invention provides aplidine derivatives and synthetic methods. They are represented by the formula: where the different symbols have the meaning indicated in the description.
(FR) L'invention concerne des dérivés d'aplidine et des procédés de synthèse.
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