EP1261619 NUCLEIC ACIDS, PROTEINS, AND ANTIBODIES

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European Patent Office

Application Number 01922228

Application Date 17.01.2001

Publication Number 1261619

Publication Date 04.12.2002

Publication Kind A1

IPC

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Applicants HUMAN GENOME SCIENCES INC

Inventors ROSEN CRAIG A
BARASH STEVEN C
RUBEN STEVEN M

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Priority Data 0101305 17.01.2001 US
24647800 08.11.2000 US
24652300 08.11.2000 US
24652400 08.11.2000 US
24660900 08.11.2000 US
24661300 08.11.2000 US
24920700 17.11.2000 US
24920800 17.11.2000 US
24920900 17.11.2000 US
24921000 17.11.2000 US
24921100 17.11.2000 US
24921200 17.11.2000 US
24921300 17.11.2000 US
24921400 17.11.2000 US
24921500 17.11.2000 US
24921600 17.11.2000 US
24921700 17.11.2000 US
24921800 17.11.2000 US
24924400 17.11.2000 US
24924500 17.11.2000 US
24926400 17.11.2000 US
24926500 17.11.2000 US
24929700 17.11.2000 US
24929900 17.11.2000 US
24930000 17.11.2000 US

Title

(DE) NUKLEINSÄUREN, PROTEINE UND ANTIKÖRPER

(EN) NUCLEIC ACIDS, PROTEINS, AND ANTIBODIES

(FR) ACIDES NUCLEIQUES, PROTEINES ET ANTICORPS

Abstract

(EN) The present invention relates to novel proteins. More specifically, isolated nucleic acid molecules are provided encoding novel polypeptides. Novel polypeptides and antibodies that bind to these polypeptides are provided. Also provided are vectors, host cells, and recombinant and synthetic methods for producing human polynucleotides and/or polypeptides, and antibodies. The invention further relates to diagnostic and therapeutic methods useful for diagnosing, treating, preventing and/or prognosing disorders related to these novel polypeptides. The invention further relates to screening methods for identifying agonists and antagonists of polynucleotides and polypeptides of the invention. The present invention further relates to methods and/or compositions for inhibiting or enhancing the production and function of the polypeptides of the present invention.

(FR) La présente invention concerne de nouvelles protéines. Plus spécifiquement, l'invention concerne des molécules d'acide nucléique isolées, codant pour de nouveaux polypeptides. Cette invention concerne également : de nouveaux polypeptides et anticorps qui se lient à ces polypeptides ; des vecteurs, des cellules hôtes, et des procédés de recombinaison et de synthèse permettant de produire des polynucléotides et/ou polypeptides humains, et des anticorps ; des procédés diagnostiques et thérapeutiques utiles pour le diagnostic, le traitement, la prévention et/ou la prévision de troubles liés à ces nouveaux polypeptides ; des procédés de criblage permettant d'identifier des agonistes et des antagonistes de polynucléotides et polypeptides de l'invention ; des procédés et/ou des compositions permettant d'inhiber ou d'augmenter la production et la fonctionnalité des polypeptides de la présente invention.

C	CHEMISTRY; METALLURGY
07	ORGANIC CHEMISTRY
H	SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
21	Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
04	with deoxyribosyl as saccharide radical

C	CHEMISTRY; METALLURGY
07	ORGANIC CHEMISTRY
H	SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
21	Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
02	with ribosyl as saccharide radical

C	CHEMISTRY; METALLURGY
07	ORGANIC CHEMISTRY
H	SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
21	Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
02	with ribosyl as saccharide radical

C	CHEMISTRY; METALLURGY
07	ORGANIC CHEMISTRY
K	PEPTIDES
5	Peptides having up to four amino acids in a fully defined sequence; Derivatives thereof

C	CHEMISTRY; METALLURGY
07	ORGANIC CHEMISTRY
H	SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
21	Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
04	with deoxyribosyl as saccharide radical

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1. EP1261619 - NUCLEIC ACIDS, PROTEINS, AND ANTIBODIES

C	CHEMISTRY; METALLURGY
12	BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N	MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
1	Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
20	Bacteria; Culture media therefor

C	CHEMISTRY; METALLURGY
12	BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
P	FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
21	Preparation of peptides or proteins
06	produced by the hydrolysis of a peptide bond, e.g. hydrolysate products

C	CHEMISTRY; METALLURGY
12	BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
Q	MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1	Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
68	involving nucleic acids