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1. (EP0981408) MICROFLUIDIC SYSTEM AND METHODS OF USE

Office : European Patent Office
Application Number: 98921307 Application Date: 15.05.1998
Publication Number: 0981408 Publication Date: 01.03.2000
Publication Kind : B1
Designated States: AT, BE, CH, CY, DE, DK, ES, FI, FR, GB, GR, IE, IT, LI, LU, MC, NL, PT, SE
Prior PCT appl.: Application Number:CA1998000481 ; Publication Number: Click to see the data
IPC:
G01N 33/49
B01J 19/00
B01J 19/08
B01L 3/00
B81B 1/00
G01N 33/15
G01N 33/50
G01N 37/00
G PHYSICS
01
MEASURING; TESTING
N
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33
Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48
Biological material, e.g. blood, urine; Haemocytometers
483
Physical analysis of biological material
487
of liquid biological material
49
blood
B PERFORMING OPERATIONS; TRANSPORTING
01
PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
J
CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS, COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
19
Chemical, physical, or physico-chemical processes in general; Their relevant apparatus
B PERFORMING OPERATIONS; TRANSPORTING
01
PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
J
CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS, COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
19
Chemical, physical, or physico-chemical processes in general; Their relevant apparatus
08
Processes employing the direct application of electric or wave energy, or particle radiation; Apparatus therefor
B PERFORMING OPERATIONS; TRANSPORTING
01
PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
L
CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
3
Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
B PERFORMING OPERATIONS; TRANSPORTING
81
MICRO-STRUCTURAL TECHNOLOGY
B
MICRO-STRUCTURAL DEVICES OR SYSTEMS, e.g. MICRO-MECHANICAL DEVICES
1
Devices without movable or flexible elements, e.g. micro-capillary devices
G PHYSICS
01
MEASURING; TESTING
N
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33
Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
15
Medicinal preparations
G PHYSICS
01
MEASURING; TESTING
N
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33
Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48
Biological material, e.g. blood, urine; Haemocytometers
50
Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
G PHYSICS
01
MEASURING; TESTING
N
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
37
Details not covered by any other group of this subclass
CPC:
B01L 3/502761
B01F 13/0059
B01J 19/0093
B01L 2200/0668
B01L 2300/0816
B01L 2300/0864
B01L 2300/0867
B01L 2400/0415
B01L 2400/0487
B81B 1/00
Y10T 436/117497
Applicants: ALBERTA RES COUNCIL
UNIV ALBERTA
Inventors: HARRISON DANIEL JED
ANDERSSON PER
LI PAUL C H
SZARKA RODERICK
SMITH RICHARD
SALIMI-MOOSAVI HOSSEIN
Priority Data: 9800481 15.05.1998 CA
4702497 19.05.1997 US
85808797 16.05.1997 US
Title: (DE) MIKROFLUIDISCHES SYSTEM UND VERFAHREN ZU DESSEN BETRIEB
(EN) MICROFLUIDIC SYSTEM AND METHODS OF USE
(FR) SYSTEME MICROFLUIDIQUE ET SES UTILISATIONS
Abstract: front page image
(EN) This invention relates to a novel microfluidic device and methods of using this device to conduct $i(in vitro) studies on the reaction and effects of various compounds on cells. More particularly, it relates to a method for using stop flow in a microfluidic system to study the effect of compounds on individual cells. It also provides a method for observing the effects of candidate compounds on leukocyte rolling.
(FR) L'invention concerne un nouveau dispositif microfluidique, ainsi que des méthodes permettant de l'utiliser pour effectuer des études $i(in vitro) sur la réaction et les effets de divers composés sur les cellules. Elle concerne plus particulièrement une méthode selon laquelle on utilise un arrêt d'écoulement dans un système microfluidique pour étudier l'effet desdits composés sur les cellules individuelles. Elle concerne également une méthode permettant d'observer les effets de composés candidats sur le roulement des leucocytes.
Also published as:
JP2002503336 CA2286601AU1998074218WO/1998/052691