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1. (EP0981359) COMPOSITIONS FOR ENHANCING IMMUNOSUPPRESSANTS' PHARMACOLOGICAL ACTIVITIES

Office : European Patent Office
Application Number: 98921528 Application Date: 18.05.1998
Publication Number: 0981359 Publication Date: 01.03.2000
Publication Kind : B1
Prior PCT appl.: Application Number:FI1998000418 ; Publication Number: Click to see the data
IPC:
A 61K
A 61K
A61K 38/00
A 61K
A61K 38/13
A 61P
A61K 38/21
A61P 43/00
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38
Medicinal preparations containing peptides
04
Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
12
Cyclic peptides
13
Cyclosporins
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38
Medicinal preparations containing peptides
04
Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38
Medicinal preparations containing peptides
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38
Medicinal preparations containing peptides
16
Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
17
from animals; from humans
19
Cytokines; Lymphokines; Interferons
21
Interferons
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38
Medicinal preparations containing peptides
04
Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
12
Cyclic peptides
13
Cyclosporins
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
37
Drugs for immunological or allergic disorders
02
Immunomodulators
06
Immunosuppressants, e.g. drugs for graft rejection
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38
Medicinal preparations containing peptides
16
Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
17
from animals; from humans
19
Cytokines; Lymphokines; Interferons
21
Interferons
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
43
Drugs for specific purposes, not provided for in groups A61P1/-A61P41/108
CPC:
A61K 38/13
A61K 38/212
Applicants: ZAVIALOV VLADIMIR PETROVICH
VASILENKO RAISA NIKOLAEVNA
DOLGIKH DMITRY ALEKSANDROVICH
KIRPICHNIKOV MIKHAIL PETROVICH
NAVOLOTSKAYA ELENA VITALIEVNA
KORPELA TIMO KALEVI
Inventors: ZAVIALOV VLADIMIR PETROVICH
VASILENKO RAISA NIKOLAEVNA
DOLGIKH DMITRY ALEKSANDROVICH
KIRPICHNIKOV MIKHAIL PETROVICH
NAVOLOTSKAYA ELENA VITALIEVNA
KORPELA TIMO KALEVI
Priority Data: 972121 19.05.1997 FI
9800418 18.05.1998 FI
Title: (DE) ZUSAMMENSETZUNGEN ZUR VERSTÄRKUNG DER PHARMAKOLOGISCHEN AKTIVITÄT VON IMMUNOSUPPRESSIVA
(EN) COMPOSITIONS FOR ENHANCING IMMUNOSUPPRESSANTS' PHARMACOLOGICAL ACTIVITIES
(FR) COMPOSITIONS STIMULANT L'ACTIVITE PHARMACOLOGIQUE DES IMMUNOSUPPRESSEURS
Abstract: front page image
(EN) The present invention provides the compositions for efficient amplification of immunosuppressive activity of cyclosporins, FK506 or rapamycin to decrease therapeutical dose of immunosuppressants, and as the consequence to avoid their undesirable side effects during organ and tissue transplantation, and treatment of different diseases. These compositions include cyclosporins, FK506 or rapamycin and biologically active peptides corresponding to the high-affinity binding/anti-lymphoproliferative site of IFNs-a,b,w,t, or recombinant proteins having the amino acid sequences corresponding to the said site.
(FR) L'invention concerne des compositions permettant d'amplifier de manière efficace l'activité immunosuppressive des ciclosporines, telles que la FK506 ou la rapamycine, de façon à diminuer leur dose thérapeutique, ce qui élimine leurs effets secondaires indésirables durant les transplantations d'organes ou de tissus et le traitement de différentes maladies. Ces compositions contiennent des ciclosporines, la FK506 ou la rapamycine, ainsi que des peptides biologiquement actifs correspondant au site de liaison à haute affinité et/ou anti-lymphoprolifératif des IFN a, b, w, t, ou bien des protéines recombinantes qui renferment des séquences d'acides aminés correspondant audit site.
Also published as:
JP2001526675 AU1998074352WO/1998/052594