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1. EP0455818 - PHYSIOLOGICALLY ACTIVE SUBSTANCE BE-16627

Office European Patent Office
Application Number 90916794
Application Date 20.11.1990
Publication Number 0455818
Publication Date 13.11.1991
Publication Kind A4
IPC
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
37
Medicinal preparations containing proteinaceous materials, lipoids, or derivatives thereof
02
Proteins; Peptides; Peptones
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
5
Peptides having up to four amino acids in a fully defined sequence; Derivatives thereof
04
containing only normal peptide links
06
Dipeptides
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38
Medicinal preparations containing peptides
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
P
FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
21
Preparation of peptides or proteins
02
having a known sequence of two or more amino acids, e.g. glutathione
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
5
Peptides having up to four amino acids in a fully defined sequence; Derivatives thereof
04
containing only normal peptide links
06
Dipeptides
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
1
Micro-organisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving micro-organisms or compositions thereof; Processes of preparing or isolating a composition containing a micro-organism; Culture media therefor
20
Bacteria; Culture media therefor
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
R
INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C-C12Q75
1
Micro-organisms
01
Bacteria or actinomycetales
465
Streptomyces
A 61K
C 07K
A61K 38/00
C 12P
C07K 5/06
C 12N
CPC
C12R 1/465
A61K 38/00
C07K 5/06069
Applicants BANYU PHARMACEUTICAL CO., LTD.
Inventors KANBAYASHI, NOBUO BANYU PHARMACEUTICAL CO., LTD.
NAITO, KYOZO BANYU PHARMACEUTICAL CO., LTD.
OKUYAMA, AKIRA BANYU PHARMACEUTICAL CO., LTD.
SUZUKI, HAJIME BANYU PHARMACEUTICAL CO., LTD.
NAKAJIMA, SHIGERU BANYU PHARMACEUTICAL CO., LTD.
SUDA, HIROYUKI BANYU PHARMACEUTICAL CO., LTD.
OKANISHI, MASANORI BANYU PHARMACEUTICAL CO., LTD.
Priority Data 30576489 24.11.1989 JP
Title
(DE) PHYSIOLOGISCH AKTIVE SUBSTANZ BE-16627.
(EN) PHYSIOLOGICALLY ACTIVE SUBSTANCE BE-16627
(FR) SUBSTANCE PHYSIOLOGIQUEMENT ACTIVE BE-16627.
Abstract
(EN)
A physiologically active substance BE-16627 which is a novel inhibitor of stromelysin (human), represented by general formula (I), wherein R is a hydrogen atom or a methyl group, or a pharmaceutically acceptable salt thereof. Also disclosed are a process for preparing the same, a use of the same as a therapeutic agent for rheumatism and a cancer metastasis inhibitor, and a microorganism which produces BE-16627.

(FR)
Substance physiologiquement active BE-16627 constituant un nouvel inhibiteur de la stromélysine (humaine) et représentée par la formule générale (I), dans laquelle R est un atome d'hydrogène ou un groupe méthyle. On décrit cette substance, un de ses sels acceptable en pharmacologie, un procédé de préparation, l'utilisation de cette substance en tant qu'agent thérapeutique contre le rhumatisme et en tant qu'inhibiteur de métastase cancéreuse, ainsi qu'un micro-organisme produisant le BE-16627.

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