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1. (EP0454831) Diazine derivatives as angiotensin II receptor antagonists.

Office : European Patent Office
Application Number: 91900302 Application Date: 19.11.1990
Publication Number: 0454831 Publication Date: 06.11.1991
Publication Kind : B1
Prior PCT appl.: Application Number:GB1990001776 ; Publication Number: Click to see the data
IPC:
C 07D
5C 07D
A 61K
A61K 31/435
5C 07D
A 61K
A61K 31/495
5C 07D
A 61K
A61K 31/50
5C 07D
A 61K
A61K 31/505
5C 07D
A61P 9/00
5C 07D
A61P 9/12
5C 07D
A61P 43/00
C07D 471/04
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
471
Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/-C07D463/251
02
in which the condensed system contains two hetero rings
04
Ortho-condensed systems
[IPC code unknown for ERROR IPC Code incorrect: invalid section (A=>H)!]
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
495
having six-membered rings with two nitrogen atoms as the only ring hetero atoms, e.g. piperazine
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
435
having six-membered rings with one nitrogen as the only ring hetero atom
[IPC code unknown for ERROR IPC Code incorrect: invalid section (A=>H)!]
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
495
having six-membered rings with two nitrogen atoms as the only ring hetero atoms, e.g. piperazine
50
Pyridazines; Hydrogenated pyridazines
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
495
having six-membered rings with two nitrogen atoms as the only ring hetero atoms, e.g. piperazine
[IPC code unknown for ERROR IPC Code incorrect: invalid section (A=>H)!]
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
495
having six-membered rings with two nitrogen atoms as the only ring hetero atoms, e.g. piperazine
505
Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
495
having six-membered rings with two nitrogen atoms as the only ring hetero atoms, e.g. piperazine
50
Pyridazines; Hydrogenated pyridazines
[IPC code unknown for ERROR IPC Code incorrect: invalid section (A=>H)!]
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
435
having six-membered rings with one nitrogen as the only ring hetero atom
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
495
having six-membered rings with two nitrogen atoms as the only ring hetero atoms, e.g. piperazine
505
Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
[IPC code unknown for ERROR IPC Code incorrect: invalid section (A=>H)!]
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
9
Drugs for disorders of the cardiovascular system
[IPC code unknown for ERROR IPC Code incorrect: invalid section (A=>H)!]
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
9
Drugs for disorders of the cardiovascular system
12
Antihypertensives
[IPC code unknown for ERROR IPC Code incorrect: invalid section (A=>H)!]
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
43
Drugs for specific purposes, not provided for in groups A61P1/-A61P41/108
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
471
Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/-C07D463/251
02
in which the condensed system contains two hetero rings
04
Ortho-condensed systems
CPC:
C07D 471/04
Applicants: ICI PLC
Inventors: ROBERTS DAVID ANTHONY HARDKNOT
PEARCE ROBERT JAMES FULSHAW AV
BRADBURY ROBERT HUGH MAINWARIN
LUKE RICHARD WILLIAM ARTHUR PI
Priority Data: 8926211 20.11.1989 GB
9001776 19.11.1990 GB
9011348 21.05.1990 GB
Title: (DE) Diazinderivate als Angiotensin II Rezeptor Antagonisten.
(EN) Diazine derivatives as angiotensin II receptor antagonists.
(FR) Dérivés de diazine comme antagonistes des recepteurs à l'angiotensine II.
Abstract:
(EN) Compounds of formula (I) where ring B is a pyridine, pyridazine, pyrimidine or pyrazine moiety; X is phenylene optionally bearing a substituent selected from (1-4C)alkyl, (1-4C)alkoxy, halogeno, trifluoromethyl, cyano and nitro, or X is a direct bond between the adjacent phenyl and methylene groups; Z is 1 $i(H)-tetrazol-5-yl, -CO.NH.(1 $i(H)-tetrazol-5-yl) or a group of the formula -CO.OR6 or -CO.NH.SO2.R7. The compounds are of value in treating conditions such as hypertentions and congestive heart failure. The inventio further concerns processes for the manufacture of the novel compounds and the use of the compounds in medical treatment.
(FR) Composés de la formule (I), dans laquelle l'anneau B représente une fraction pyridine, pyridazine, pyrimidine ou pyrazine; X représente phénylène supportant facultativement un substituant choisi entre alkyle contenant 1 à 4 atomes de carbone, alcoxy contenant 1 à 4 atomes de carbone, alcoxy contenant 1 à 4 atomes de carbone, halogéno, trifluorométhyle, cyano et nitro, ou X représente une liaison directe entre les groupes phényle et méthylène adjacents; Z représente 1 $i(H)-tétrazol-5-yle, -CO.NH.(1 $i(H)-tétrazol-5-yle) ou un groupe de la formule -CO.OR6 ou -CO.NH.SO2R7. Les composés sont efficaces dans le traitement d'états tels que l'hypertension et l'insuffisance cardiaque. L'invention concerne également des procédés de fabrication des nouveaux composés, ainsi que l'emploi de ceux-ci en traitement médical.
Also published as:
FI913478NO19912843KR1019920701206AU1990067336WO/1991/007404