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1. EP0263102 - A cDNA MOLECULE CODING FOR THE EXPRESSION OF AN INTERFERON -g(a) TYPE POLYPEPTIDE, A BACTERIAL OR CELLULAR HOST TRANSFORMED WITH SUCH MOLECULE AND A POLYPEPTIDE SHOWING INTERFERON ACTIVITY PREPARED BY SUCH HOST.

Office
European Patent Office
Application Number 86903650
Application Date 14.05.1986
Publication Number 0263102
Publication Date 13.04.1988
Publication Kind A1
IPC
C07K 15/26
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
15Peptides or proteins having an unknown or only partially known sequence of aminoacids; Derivatives thereof
26Interferons
C12N 15/00
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
C12N 15/00
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
C12P 21/02
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
21Preparation of peptides or proteins
02having a known sequence of two or more amino acids, e.g. glutathione
A61K 38/21
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
17from animals; from humans
19Cytokines; Lymphokines; Interferons
21Interferons
C07K 14/52
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435from animals; from humans
52Cytokines; Lymphokines; Interferons
CPC
C07K 14/56
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435from animals; from humans
52Cytokines; Lymphokines; Interferons
555Interferons [IFN]
56IFN-alpha
Applicants KABIVITRUM AB
Inventors VON GABAIN ALEXANDER ULRICH
LUND BJOERN OLOF
EDLUND THOMAS BERNHARD
NY TOR ERIK ROGER
LUNDGREN ERIK HUGO OLAUS
Designated States
Priority Data 8502430 15.05.1985 SE
Title
(DE) CDNS-MOLEKÜLE KODIEREND FÜR INTERFERON-TYP-POLYPEPTID, BAKTERIELLER UND ZELLULÄRER GAST MIT SOLCHEN MOLEKÜLEN TRANSFORMIERT SOWIE POLYPEPTID MIT INTERFERONWIRKUNG.
(EN) A cDNA MOLECULE CODING FOR THE EXPRESSION OF AN INTERFERON -g(a) TYPE POLYPEPTIDE, A BACTERIAL OR CELLULAR HOST TRANSFORMED WITH SUCH MOLECULE AND A POLYPEPTIDE SHOWING INTERFERON ACTIVITY PREPARED BY SUCH HOST.
(FR) MOLECULE D'ADNc CODANT POUR L'EXPRESSION D'UN POLYPEPTIDE -i(a) D'INTERFERON, HOTE BACTERIEN OU CELLULAIRE TRANSFORME A L'AIDE DE CETTE MOLECULE ET POLYPEPTIDE PREPARE PAR LEDIT HOTE ET PRESENTANT UNE ACTIVITE D'INTERFERON.
Abstract
(EN) A cDNA molecule having the nucleotide sequence ($g(a)-88) (I) or sequences which hybridize to the foregoing sequence and which code for the expression of a polypeptide of the IFN-$g(a) type; or sequences which are degenerate as a result of the genetic code to the nucleotide sequence defined above and which code for the expression of a polypeptide of the IFN-$g(a) type; a bacterial or cellular host transformed with such molecule; a polypeptide having $g(a)-type interfering activity prepared by such host; and method of therapeutical treatment.
(FR) Molécule d'ADNc possédant la séquence de nucléotide ($g(a)-88) (I) ou séquences subissant une hybridation en la séquence précédente et qui codent l'expression d'un polypeptide du type IFN-$g(a), ou séquences qui dégénèrent à la suite du code génétique en la séquence de nucléotide définie ci-dessus et qui codent l'expression d'un polypeptide du type IFN-$g(a); un hôte bactérien ou cellulaire transformé par cette molécule; un polypeptide possédant une activité d'interféron du type $g(a) préparé par ledit hôte, et procédé de traitement thérapeutique.
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