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1. EP2194485 - Method and apparatus for reading coded microbeads

Office
European Patent Office
Application Number 10000325
Application Date 16.11.2005
Publication Number 2194485
Publication Date 09.06.2010
Publication Kind B1
IPC
G06K 7/10
GPHYSICS
06COMPUTING; CALCULATING OR COUNTING
KRECOGNITION OF DATA; PRESENTATION OF DATA; RECORD CARRIERS; HANDLING RECORD CARRIERS
7Methods or arrangements for sensing record carriers
10by electromagnetic radiation, e.g. optical sensing; by corpuscular radiation
G01N 15/00
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
15Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
G01N 33/543
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48Biological material, e.g. blood, urine; Haemocytometers
50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
53Immunoassay; Biospecific binding assay; Materials therefor
543with an insoluble carrier for immobilising immunochemicals
G02B 1/00
GPHYSICS
02OPTICS
BOPTICAL ELEMENTS, SYSTEMS, OR APPARATUS
1Optical elements characterised by the material of which they are made; Optical coatings for optical elements
G02B 27/46
GPHYSICS
02OPTICS
BOPTICAL ELEMENTS, SYSTEMS, OR APPARATUS
27Optical systems or apparatus not provided for by any of the groups G02B1/-G02B26/119
42Diffraction optics
46Systems using spatial filters
CPC
B01J 2219/00459
BPERFORMING OPERATIONS; TRANSPORTING
01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
2219Chemical, physical or physico-chemical processes in general; Their relevant apparatus
00274Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
00277Apparatus
00457Dispensing or evacuation of the solid phase support
00459Beads
B01J 2219/005
BPERFORMING OPERATIONS; TRANSPORTING
01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
2219Chemical, physical or physico-chemical processes in general; Their relevant apparatus
00274Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
00277Apparatus
00497Features relating to the solid phase supports
005Beads
B01J 2219/00704
BPERFORMING OPERATIONS; TRANSPORTING
01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
2219Chemical, physical or physico-chemical processes in general; Their relevant apparatus
00274Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
0068Means for controlling the apparatus of the process
00702Processes involving means for analysing and characterising the products
00704integrated with the reactor apparatus
B82Y 20/00
BPERFORMING OPERATIONS; TRANSPORTING
82NANOTECHNOLOGY
YSPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
20Nanooptics, e.g. quantum optics or photonic crystals
G01N 15/1468
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
15Investigating characteristics of particles; Investigating permeability, pore-volume, or surface-area of porous materials
10Investigating individual particles
14Electro-optical investigation, e.g. flow cytometers
1468with spatial resolution of the texture or inner structure of the particle
G02B 1/005
GPHYSICS
02OPTICS
BOPTICAL ELEMENTS, SYSTEMS, OR APPARATUS
1Optical elements characterised by the material of which they are made
002made of materials engineered to provide properties not available in nature, e.g. metamaterials
005made of photonic crystals or photonic band gap materials
Applicants ILLUMINA INC
Inventors MOON JOHN A
PUTNAM MARTIN A
Designated States
Priority Data 05851776 16.11.2005 EP
62889704 16.11.2004 US
Title
(DE) Verfahren und Vorrichtung zum Auslesen kodierter Mikroperlen
(EN) Method and apparatus for reading coded microbeads
(FR) Procédés et appareils pour la lecture de microbilles codées
Abstract
(EN) The present invention relates to a unique method and apparatus for reading a microbead having a code thereon, wherein the code is projected on and read from a Fourier plane. When illuminated by an incident light, comprising a reading device positioned to detect optical signals from the Fourier plane and a processor configured to perform Fourier plane analysis of the optical signals projected onto the Fourier plane to determine corresponding codes of the encoded microbeads.
(FR) L'invention concerne un procédé et un appareil permettant de lire une microbille dotée d'un code, le code étant projeté sur un plan Fourier et lu depuis de plan Fourier. La microbille a une largeur de ligne de 1-1000 microns (um) maximum. Le code est projeté sur le plan de Fourier par diffusion d'une lumière d'entrée depuis la microbille. La lumière diffusée depuis la microbille est dirigée à travers un système optique ayant une lentille de transformée pour la projection du code sur le plan de Fourier et lue sur le plan de Fourier à l'aide d'un dispositif couplé de charge (CCD) ou autre dispositif similaire. Le code peut contenir des couches périodiques de matière ayant différentes réfringences ou phases, y compris des différences d'indice de réfraction, des modulations spatiales périodiques ayant une phase ou une amplitude différtente; un changement de phase binaire périodique destiné au codage de l'information dans le plan de Fourier ; un cristal photonique destiné au codage de l'information sur la microbille. Un motif de trous provoque des interférences entre la lumière incidente et la lumière diffusée pour former des motifs spatiaux et spectraux dans le champ lointain qui sont uniques au motif de trous ou peuvent être formés dans la microbille à l'aide d'une zone interne photoactive unique, une série de trous longitudinaux, de différentes régions de fluorescence ou des anneaux concentriques de matière dans une préforme.