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1. EP2099445 - P53 ACTIVATING BENZOYL UREA AND BENZOYL THIOUREA COMPOUNDS

Office
European Patent Office
Application Number 07804108
Application Date 04.09.2007
Publication Number 2099445
Publication Date 16.09.2009
Publication Kind B1
IPC
A61K 31/17
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
16Amides, e.g. hydroxamic acids
17having the group N-C(O)-N or N-C(S)-N, e.g. urea, thiourea, carmustine
CPC
A61P 3/04
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
3Drugs for disorders of the metabolism
04Anorexiants; Antiobesity agents
A61P 3/10
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
3Drugs for disorders of the metabolism
08for glucose homeostasis
10for hyperglycaemia, e.g. antidiabetics
A61P 9/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
9Drugs for disorders of the cardiovascular system
A61P 9/04
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
9Drugs for disorders of the cardiovascular system
04Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
A61P 21/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
21Drugs for disorders of the muscular or neuromuscular system
A61P 25/28
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25Drugs for disorders of the nervous system
28for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
Applicants UNIV DUNDEE
UNIV ST ANDREWS
Inventors LAIN SONIA
LANE DAVID PHILLIP
STARK MICHAEL JOHN RAYMOND
MCCARTHY ANNA ROSE
HOLLICK JONATHAN JAMES
WESTWOOD NICHOLAS JAMES
Designated States
Priority Data 0617278 04.09.2006 GB
0625929 23.12.2006 GB
Title
(DE) P53 AKTIVIERENDE BENZOYLHARNSTOFF- UND BENZOYLTHIOHARNSTOFF-VERBINDUNGEN
(EN) P53 ACTIVATING BENZOYL UREA AND BENZOYL THIOUREA COMPOUNDS
(FR) DERIVES DE LA BENZOYL-UREE ET DE LA BENZOYL-THIO-UREE A ACTIVATION DE P53
Abstract
(EN) The present invention relates to compounds which acivate the p53 response, and find use in, for example, hyperproliferative diseases such as cancer treatment and potentially other diseases/conditions (involving sirtuin function).
(FR) La présente invention concerne des composés qui activent la réponse de P53, et s'emploient, par exemple, dans le traitement de maladies hyperprolifératives comme le cancer et, éventuellement, d'autres maladies ou états (impliquant la fonction de la sirtuine).