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1. EP2060584 - Method for the production of proteins with chemically functionalized N-termini

Office European Patent Office
Application Number 07020231
Application Date 16.10.2007
Publication Number 2060584
Publication Date 20.05.2009
Publication Kind A1
IPC
C07K 14/485
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435from animals; from humans
475Growth factors; Growth regulators
485Epidermal growth factor (EGF) (urogastrone)
C07K 1/107
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
1General processes for the preparation of peptides
107by chemical modification of precursor peptides
C12P 1/04
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
1Preparation of compounds or compositions, not provided for in groups C12P3/-C12P39/121; General processes for the preparation of compounds or compositions by using microorganisms or enzymes
04by using bacteria
CPC
C07K 14/485
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435from animals; from humans
475Growth factors; Growth regulators
485Epidermal growth factor [EGF] (urogastrone)
C12P 21/005
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
21Preparation of peptides or proteins
005Glycopeptides, glycoproteins
C12P 21/02
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
21Preparation of peptides or proteins
02having a known sequence of two or more amino acids, e.g. glutathione
Applicants MAX PLANCK GESELLSCHAFT
Inventors BUDISA NEDILJKO
MERKEL LARS
CHEBURKIN YURI
ULLRICH AXEL
KNYAZEV PIOTR
WILTSCHI BIRGIT
Designated States
Priority Data 07020231 16.10.2007 EP
Title
(DE) Verfahren zur Herstellung von Proteinen mit chemisch funktionalisierten N-Termini
(EN) Method for the production of proteins with chemically functionalized N-termini
(FR) Procédé pour la production de protéines dotées de n-terminaisons à fonction chimique
Abstract
(EN)
The present invention refers to the production of N-terminally modified polypeptides, wherein an N-terminal methionine residue is replaced by a non-genetically encoded amino acid residue. The non-genetically coded amino acid residue may comprise a functional chemical moiety for coupling two heterologous molecules, e.g. reporter or effector molecules.