EA201391325 ПРОИЗВОДНЫЕ ЦЕФАЛОСПОРИНА И ИХ ФАРМАЦЕВТИЧЕСКИЕ КОМПОЗИЦИИ

Settings

Stemming

Single Family Member

Include NPL

Feedback

Goto Application

Office

Eurasian Patent Organization

Application Number 201391325

Application Date 29.03.2012

Publication Number 201391325

Publication Date 30.04.2014

Grant Number 024709

Grant Date 31.10.2016

Publication Kind B1

IPC

CPC

View more classifications

View less classifications

Applicants ЛЕГОКЕМ БАЙОСАЙЕНСИЗ, ИНК.
LEGOCHEM BIOSCIENCES, INC.

Inventors Чо Юн Лаг
Йоун Джоун Йуль
Парк Чуль Сун
Чае Сан Еунь
Ли Ньян Сук
Ох Кьюман
Хео Хье Джинь
Кан Дае Хьюк
Ян Юн Джае
Квон Хьюнь Джинь
Парк Тае Кью
Ву Сун Хо
Ким Йон Зу
CHO Young, Lag
YUN Joung, Yul
PARK Chul, Soon
CHAE Sang, Eun
LEE Hyang, Sook
OH Kyuman
HEO Hye, Jin
KANG Dae, Hyuck
YANG Young, Jae
KWON Hyun, Jin
PARK Tae, Kyo
WOO Sung, Ho
KIM Yong, Zu

Agents Поликарпов Александр Викторович
Polikarpov Aleksandr, V.

Priority Data 1020110028603 30.03.2011 KR

Title

(RU) ПРОИЗВОДНЫЕ ЦЕФАЛОСПОРИНА И ИХ ФАРМАЦЕВТИЧЕСКИЕ КОМПОЗИЦИИ

Abstract

(RU)

Изобретение относится к новым производным цефалоспорина, представленным химической формулой (1)

где X, Y, L, R₁, R₂ и R₃ являются такими, как определено в описании изобретения. Изобретение также относится к фармацевтическим антибиотическим композициям, содержащим новое производное цефалоспорина, представленное химической формулой (1), его пролекарство, его гидрат, его сольват, его изомер или его фармацевтически приемлемую соль в качестве эффективного ингредиента. Согласно изобретению предложены новые производные цефалоспорина, их пролекарство, их гидрат, их сольват, их изомер или их фармацевтически приемлемая соль в качестве ингредиента с низкой токсичностью, эффективного в отношении широкого спектра устойчивых к антибиотикам бактерий, в частности грамотрицательных, который может быть полезен сильной антимикробной активностью.

C	CHEMISTRY; METALLURGY
07	ORGANIC CHEMISTRY
D	HETEROCYCLIC COMPOUNDS
501	Heterocyclic compounds containing 5-thia-1-azabicyclo octane ring systems, i.e. compounds containing a ring system of the formula: , e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
14	Compounds having a nitrogen atom directly attached in position 7
16	with a double bond between positions 2 and 3
20	7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
24	with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
26	Methylene radicals, substituted by oxygen atoms; Lactones thereof with the 2-carboxyl group
34	with the 7-amino radical acylated by carboxylic acids containing hetero rings

C	CHEMISTRY; METALLURGY
07	ORGANIC CHEMISTRY
D	HETEROCYCLIC COMPOUNDS
501	Heterocyclic compounds containing 5-thia-1-azabicyclo octane ring systems, i.e. compounds containing a ring system of the formula: , e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
14	Compounds having a nitrogen atom directly attached in position 7
16	with a double bond between positions 2 and 3
20	7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
24	with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
26	Methylene radicals, substituted by oxygen atoms; Lactones thereof with the 2-carboxyl group
34	with the 7-amino radical acylated by carboxylic acids containing hetero rings

C	CHEMISTRY; METALLURGY
07	ORGANIC CHEMISTRY
D	HETEROCYCLIC COMPOUNDS
501	Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula: , e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
02	Preparation
04	from compounds already containing the ring or condensed ring systems, e.g. by dehydrogenation of the ring, by introduction, elimination or modification of substituents

C	CHEMISTRY; METALLURGY
07	ORGANIC CHEMISTRY
D	HETEROCYCLIC COMPOUNDS
501	Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula: , e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
14	Compounds having a nitrogen atom directly attached in position 7
16	with a double bond between positions 2 and 3
20	7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
24	with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
38	Methylene radicals, substituted by nitrogen atoms; Lactams thereof with the 2-carboxyl group; Methylene radicals substituted by nitrogen-containing hetero rings attached by the ring nitrogen atom; Quaternary compounds thereof
46	with the 7-amino radical acylated by carboxylic acids containing hetero rings

C	CHEMISTRY; METALLURGY
07	ORGANIC CHEMISTRY
D	HETEROCYCLIC COMPOUNDS
501	Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula: , e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
14	Compounds having a nitrogen atom directly attached in position 7
16	with a double bond between positions 2 and 3
20	7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
24	with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3

Processing

National Phase Entries

Authority File

Settings

Feedback

Goto Application

1. EA201391325 - ПРОИЗВОДНЫЕ ЦЕФАЛОСПОРИНА И ИХ ФАРМАЦЕВТИЧЕСКИЕ КОМПОЗИЦИИ

A	HUMAN NECESSITIES
61	MEDICAL OR VETERINARY SCIENCE; HYGIENE
P	SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
31	Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics

Y	SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
02	TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
A	TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
50	in human health protection, e.g. against extreme weather
30	Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change