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1. (EA201100829) COMPOSITION CONTAINING SMALL LIPOSOMES AND METHOD FOR PREPARATION THEREOF

Office : Eurasian Patent Organization
Application Number: 201100829 Application Date: 17.12.2009
Publication Number: 201100829 Publication Date: 28.02.2012
Grant Number: 020604 Grant Date: 30.12.2014
Publication Kind : B1
Prior PCT appl.: Application Number:PCTUS2009068499 ; Publication Number:WO2010078045 Click to see the data
IPC:
A61K 9/127
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9
Medicinal preparations characterised by special physical form
10
Dispersions; Emulsions
127
Liposomes
CPC:
C07F 9/10
A61K 9/1277
A61K 39/00
Applicants: ОНКОТИРЕОН, ИНК.
ONCOTHYREON, INC.
Inventors: Дюпуи Роберт А.
Рейли Уильям Дж.
DUPUIT Robert, A.
REILLEY William, J.
Agents: Дементьев Владимир Николаевич
Dementyev Vladimir, N.
Priority Data: 61/138,353 17.12.2008 US
Title: (EN) COMPOSITION CONTAINING SMALL LIPOSOMES AND METHOD FOR PREPARATION THEREOF
(RU) КОМПОЗИЦИЯ, СОДЕРЖАЩАЯ ЛИПОСОМЫ МАЛОГО РАЗМЕРА, И СПОСОБ ЕЕ ПОЛУЧЕНИЯ
Abstract: front page image
(EN)

Liposomes of constrained particle size are prepared by substantially continuously mixing substantially continuously flowing streams of water, and of an organic solvent contain lipid(s) capable of forming liposomes, and cooling the mixture so liposomes form, the ratio of the flow rate of the stream of water to the flow rate of the stream of organic solvent, and the rate of cooling of said mixture, being controlled so as to obtain a preparation of liposomes such that at least about 90% of the liposomes are of a particle size less than about 200 nm.


(RU)

Липосомы с размерами в ограниченном интервале получают при практически непрерывном смешивании практически постоянных потоков воды и органического растворителя, который содержит липид(ы), способные образовывать липосомы, с последующим охлаждением смеси полученных липосом, причем соотношение скоростей потока воды и потока органического растворителя и скорость охлаждения указанной смеси регулируют таким образом, чтобы по меньшей мере примерно 90% липосом имели размер менее примерно 200 нм.


Also published as:
EP2367532SG172257JP2012512260US20120034294CN102256595CA2747182
JP2014224127MX2011006562KR1020110094114CN105935352AU2009333177AU2013273711
IN2997/KOLNP/2011BRPI0923001WO/2010/078045