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1. EA201000642 - 2'-FLUORO-2'-DEOXYTETRAHYDROURIDINES AS CYTIDINE DEAMINASE INHIBITORS

Office
Eurasian Patent Organization
Application Number 201000642
Application Date 16.10.2008
Publication Number 201000642
Publication Date 29.10.2010
Grant Number 018757
Grant Date 30.10.2013
Publication Kind B1
IPC
C07H 19/04
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
19Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro derivatives thereof
02sharing nitrogen
04Heterocyclic radicals containing only nitrogen as ring hetero atom
CPC
A61K 31/7068
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
70Carbohydrates; Sugars; Derivatives thereof
7042Compounds having saccharide radicals and heterocyclic rings
7052having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
706containing six-membered rings with nitrogen as a ring hetero atom
7064containing condensed or non-condensed pyrimidines
7068having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
A61P 35/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35Antineoplastic agents
A61P 35/02
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35Antineoplastic agents
02specific for leukemia
A61P 35/04
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35Antineoplastic agents
04specific for metastasis
A61P 43/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
43Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
C07H 1/00
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
1Processes for the preparation of sugar derivatives
Applicants ЭЙСАЙ ИНК. null
EISAI INC. null
Inventors Гамильтон Грегори С.
Цукамото Такаси
Феррарис Дана В.
Дюваль Бриджит
Лапидус Рена
HAMILTON Gregory, S.
TSUKAMOTO Takashi
FERRARIS Dana, V.
DUVALL Bridget
LAPIDUS Rena
Agents Агуреев Александр Павлович
Agureev Alexandre, P.
Priority Data 60/980,397 16.10.2007 US
Title
(EN) 2'-FLUORO-2'-DEOXYTETRAHYDROURIDINES AS CYTIDINE DEAMINASE INHIBITORS
(RU) 2'-ФТОР-2'-ДЕЗОКСИТЕТРАГИДРОУРИДИНЫ В КАЧЕСТВЕ ИНГИБИТОРОВ ЦИТИДИНДЕАМИНАЗЫ
Abstract
(EN)

The present invention relates to compounds of formula I or pharmaceutical acceptable salt thereof:

wherein the carbon marked by an asterisk * may have an (R) or an (S) configuration; and wherein R1 and R2 are fluorine, pharmaceutical compositions and kits comprising such compounds, and methods of making and using such compounds.


(RU)

Настоящее изобретение относится к соединениям формулы I или их фармацевтически приемлемым солям

где атом углерода, отмеченный символом *, может находиться в (R)- или (S)-конфигурации; и R1 и R2 представляют собой фтор, фармацевтическим композициям и наборам, включающим указанные соединения, а также к способам получения и применению указанных соединений.


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