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1. EA200000551 - α-HYDROXY, -AMINO AND -FLUORO DERIVATIVES OF β-SULPHONYL HYDROXAMIC ACIDS AS MATRIX METALLOPROTEINASES INHIBITORS

Office
Eurasian Patent Organization
Application Number 200000551
Application Date 18.11.1998
Publication Number 200000551
Publication Date 30.10.2000
Grant Number 003585
Grant Date 26.06.2003
Publication Kind B1
IPC
C07C 317/44
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
317Sulfones; Sulfoxides
44having sulfone or sulfoxide groups and carboxyl groups bound to the same carbon skeleton
CPC
A61P 1/02
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
1Drugs for disorders of the alimentary tract or the digestive system
02Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
A61P 1/04
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
1Drugs for disorders of the alimentary tract or the digestive system
04for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
A61P 11/06
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
11Drugs for disorders of the respiratory system
06Antiasthmatics
A61P 13/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
13Drugs for disorders of the urinary system
A61P 13/10
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
13Drugs for disorders of the urinary system
10of the bladder
A61P 17/02
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
17Drugs for dermatological disorders
02for treating wounds, ulcers, burns, scars, keloids, or the like
Applicants ФАРМАЦИЯ ЭНД АПДЖОН КОМПАНИ null
PHARMACIA & UPJOHN COMPANY null
Inventors Варпехоски Марта А.
Митчелл Марк Аллен
Харпер Дональд Е.
Маджора Линда Луиза
WARPEHOSKI Martha, A
MITCHELL Mark, Allen
HARPER Donald, E
MAGGOIRA Linda, Louise
Agents Медведев Валерий Николаевич
Павловский Анатолий Николаевич
Medvedev V, N
Pavlovsky A, N
Priority Data 60/072,655 21.11.1997 US
Title
(EN) α-HYDROXY, -AMINO AND -FLUORO DERIVATIVES OF β-SULPHONYL HYDROXAMIC ACIDS AS MATRIX METALLOPROTEINASES INHIBITORS
(RU) α-ГИДРОКСИ, -АМИНО И ГАЛОИДНЫЕ ПРОИЗВОДНЫЕ β-СУЛЬФОНИЛГИДРОКСАМОВЫХ КИСЛОТ В КАЧЕСТВЕ ИНГИБИТОРОВ МАТРИКСНЫХ МЕТАЛЛОПРОТЕИНАЗ
Abstract
(RU)

Предложены ингибирующие различные ферменты из семейства матриксных металлопротеиназ соединения формулы I или их фармацевтически приемлемые соли, где R1 - незамещенный или замещенный фенил; R2 - замещенный фенилсульфонилметил или группа -CH2NHC(=O)R3, где R3 - С5-6циклоалкил или фенил, необязательно замещенный C1-4алкокси; Y - ОН, а также промежуточные соединения для их синтеза, фармацевтическая композиция, применение соединений для ингибирования матриксной металлопротеиназы и лечения человека, страдающего от или предрасположенного к заболеванию, включающему деградацию соединительной ткани, способы ингибирования и лечения.


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