EA202092117 ТЕРАПЕВТИЧЕСКИЕ КОМПОЗИЦИИ 4'-ГАЛОГЕНСОДЕРЖАЩИХ НУКЛЕОТИДОВ И НУКЛЕОЗИДОВ И ИХ ПРИМЕНЕНИЕ

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Eurasian Patent Organization

Application Number 202092117

Application Date 07.03.2019

Publication Number 202092117

Publication Date 28.06.2021

Publication Kind A1

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Applicants ЭМОРИ ЮНИВЕРСИТИ

Inventors Пэйнтер Джордж Р.
Перриман Дэвид
Блумлинг Грегори Р.

Agents Хмара Михаил Васильевич

Priority Data 62/639,725 07.03.2018 US

Title

(RU) ТЕРАПЕВТИЧЕСКИЕ КОМПОЗИЦИИ 4'-ГАЛОГЕНСОДЕРЖАЩИХ НУКЛЕОТИДОВ И НУКЛЕОЗИДОВ И ИХ ПРИМЕНЕНИЕ

Abstract

(RU)

Описаны терапевтические композиции галогенсодержащих нуклеотидов и нуклеозидов и их применение. В некоторых вариантах реализации настоящее изобретение относится к лечению или профилактике вирусных инфекций. Такие вирусные инфекции могут включать тогавирусы, буньявирусы, аренавирусы, коронавирусы, флавивирусы, пикорнавирусы, восточный, западный и венесуэльский лошадиный энцефалит (EEE, WEE и VEE соответственно), лихорадку Чикунгунья (CHIK), инфекции вирусов Эбола, гриппа, RSV и вируса Зика.

C	CHEMISTRY; METALLURGY
07	ORGANIC CHEMISTRY
D	HETEROCYCLIC COMPOUNDS
307	Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
02	not condensed with other rings
04	having no double bonds between ring members or between ring members and non-ring members
10	with substituted hydrocarbon radicals attached to ring carbon atoms
12	Radicals substituted by oxygen atoms

C	CHEMISTRY; METALLURGY
07	ORGANIC CHEMISTRY
D	HETEROCYCLIC COMPOUNDS
307	Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
02	not condensed with other rings
04	having no double bonds between ring members or between ring members and non-ring members
10	with substituted hydrocarbon radicals attached to ring carbon atoms
12	Radicals substituted by oxygen atoms

A	HUMAN NECESSITIES
61	MEDICAL OR VETERINARY SCIENCE; HYGIENE
K	PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31	Medicinal preparations containing organic active ingredients
33	Heterocyclic compounds
395	having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
495	having six-membered rings with two ; or more; nitrogen atoms as the only ring heteroatoms, e.g. piperazine ; or tetrazines
505	Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim

C	CHEMISTRY; METALLURGY
07	ORGANIC CHEMISTRY
H	SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
19	Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides ; Anhydro-derivatives thereof
02	sharing nitrogen
04	Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
06	Pyrimidine radicals

C	CHEMISTRY; METALLURGY
07	ORGANIC CHEMISTRY
H	SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
19	Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides ; Anhydro-derivatives thereof
02	sharing nitrogen
04	Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
06	Pyrimidine radicals
067	with ribosyl as the saccharide radical

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1. EA202092117 - ТЕРАПЕВТИЧЕСКИЕ КОМПОЗИЦИИ 4'-ГАЛОГЕНСОДЕРЖАЩИХ НУКЛЕОТИДОВ И НУКЛЕОЗИДОВ И ИХ ПРИМЕНЕНИЕ

A	HUMAN NECESSITIES
61	MEDICAL OR VETERINARY SCIENCE; HYGIENE
P	SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
31	Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
12	Antivirals

A	HUMAN NECESSITIES
61	MEDICAL OR VETERINARY SCIENCE; HYGIENE
K	PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9	Medicinal preparations characterised by special physical form
0012	Galenical forms characterised by the site of application
007	Pulmonary tract; Aromatherapy
0073	Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy;
008	comprising drug dissolved or suspended in liquid propellant for inhalation via a pressurized metered dose inhaler [MDI]