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1. EA202092117 - ТЕРАПЕВТИЧЕСКИЕ КОМПОЗИЦИИ 4'-ГАЛОГЕНСОДЕРЖАЩИХ НУКЛЕОТИДОВ И НУКЛЕОЗИДОВ И ИХ ПРИМЕНЕНИЕ

Office
Eurasian Patent Organization
Application Number 202092117
Application Date 07.03.2019
Publication Number 202092117
Publication Date 28.06.2021
Publication Kind A1
IPC
C07D 307/12
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
307Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
02not condensed with other rings
04having no double bonds between ring members or between ring members and non-ring members
10with substituted hydrocarbon radicals attached to ring carbon atoms
12Radicals substituted by oxygen atoms
CPC
A61K 31/505
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
495having six-membered rings with two ; or more; nitrogen atoms as the only ring heteroatoms, e.g. piperazine ; or tetrazines
505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
C07H 19/06
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
19Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides ; Anhydro-derivatives thereof
02sharing nitrogen
04Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
06Pyrimidine radicals
C07H 19/067
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
19Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides ; Anhydro-derivatives thereof
02sharing nitrogen
04Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
06Pyrimidine radicals
067with ribosyl as the saccharide radical
C07H 19/20
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
19Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides ; Anhydro-derivatives thereof
02sharing nitrogen
04Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
16Purine radicals
20with the saccharide radical esterified by phosphoric or polyphosphoric acids
C07H 19/207
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
19Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides ; Anhydro-derivatives thereof
02sharing nitrogen
04Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
16Purine radicals
20with the saccharide radical esterified by phosphoric or polyphosphoric acids
207the phosphoric or polyphosphoric acids being esterified by a further hydroxylic compound, e.g. flavine adenine dinucleotide or nicotinamide-adenine dinucleotide
A61P 31/12
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
31Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
12Antivirals
Applicants ЭМОРИ ЮНИВЕРСИТИ
Inventors Пэйнтер Джордж Р.
Перриман Дэвид
Блумлинг Грегори Р.
Agents Хмара Михаил Васильевич
Priority Data 62/639,725 07.03.2018 US
Title
(RU) ТЕРАПЕВТИЧЕСКИЕ КОМПОЗИЦИИ 4'-ГАЛОГЕНСОДЕРЖАЩИХ НУКЛЕОТИДОВ И НУКЛЕОЗИДОВ И ИХ ПРИМЕНЕНИЕ
Abstract
(RU)

Описаны терапевтические композиции галогенсодержащих нуклеотидов и нуклеозидов и их применение. В некоторых вариантах реализации настоящее изобретение относится к лечению или профилактике вирусных инфекций. Такие вирусные инфекции могут включать тогавирусы, буньявирусы, аренавирусы, коронавирусы, флавивирусы, пикорнавирусы, восточный, западный и венесуэльский лошадиный энцефалит (EEE, WEE и VEE соответственно), лихорадку Чикунгунья (CHIK), инфекции вирусов Эбола, гриппа, RSV и вируса Зика.


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