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1. EA201692255 - УЛУЧШЕННЫЕ ФОРМЫ СЕЛЕКТИВНОГО ИНГИБИТОРА PI3K-ДЕЛЬТА ДЛЯ ПРИМЕНЕНИЯ В ФАРМАЦЕВТИЧЕСКИХ ПРЕПАРАТАХ

Office
Eurasian Patent Organization
Application Number 201692255
Application Date 26.05.2015
Publication Number 201692255
Publication Date 28.04.2017
Grant Number 032506
Grant Date 28.06.2019
Publication Kind B1
IPC
C07D 487/04
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
487Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/-C07D477/183
02in which the condensed system contains two hetero rings
04Ortho-condensed systems
CPC
C07D 487/04
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
487Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by C07D451/00 - C07D477/00
02in which the condensed system contains two hetero rings
04Ortho-condensed systems
C07B 2200/13
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
BGENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
2200Indexing scheme relating to specific properties of organic compounds
13Crystalline forms, e.g. polymorphs
A61P 29/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
29Non-central analgesic, antipyretic or anti-inflammatory agents, e.g antirheumatic agents; Non-steroidal anti-inflammatory drugs (NSAIDs)
A61P 35/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35Antineoplastic agents
A61K 31/519
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
495having six-membered rings with two ; or more; nitrogen atoms as the only ring heteroatoms, e.g. piperazine ; or tetrazines
505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
519ortho- or peri-condensed with heterocyclic rings
A61K 45/06
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
45Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
Applicants РИЗЕН ФАРМАСЬЮТИКАЛЗ СА
RHIZEN PHARMACEUTICALS SA
Inventors Ваккаланка Сваруп Кумар Венката Сатья
VAKKALANKA Swaroop, Kumar, Venkata, Satya
Agents Нилова Мария Иннокентьевна
Nilova Maria, I.
Priority Data 2596/CHE/2014 27.05.2014 IN
2597/CHE/2014 27.05.2014 IN
Title
(RU) УЛУЧШЕННЫЕ ФОРМЫ СЕЛЕКТИВНОГО ИНГИБИТОРА PI3K-ДЕЛЬТА ДЛЯ ПРИМЕНЕНИЯ В ФАРМАЦЕВТИЧЕСКИХ ПРЕПАРАТАХ
Abstract
(RU)

Изобретение относится к твердофазным формам соли п-толуолсульфоновой кислоты (ПТСК) селективного ингибитора PI3K-дельта (S)-2-(1-(4-амино-3-(3-фтор-4-изопропоксифенил)-1H-пиразоло[3,4-d]пиримидин-1-ил)этил)-6-фтор-3-(3-фторфенил)-4H-хромен-4-она (TGR-1202). Изобретение также относится к способам получения указанных соединений, содержащим их фармацевтическим композициям и способам лечения опосредованных киназой PI3K (фосфатидилинозитол-3-киназой).