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1. EA201692018 - ПРОЛЕКАРСТВА ЯНТАРНОЙ КИСЛОТЫ ДЛЯ ПОВЫШЕНИЯ ПРОИЗВОДСТВА ATP

Office
Eurasian Patent Organization
Application Number 201692018
Application Date 08.04.2015
Publication Number 201692018
Publication Date 28.04.2017
Publication Kind A1
IPC
C07D 319/06
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
319Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
041,3-Dioxanes; Hydrogenated 1,3-dioxanes
06not condensed with other rings
CPC
C07C 69/40
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
69Esters of carboxylic acids; Esters of carbonic or haloformic acids
34Esters of acyclic saturated polycarboxylic acids having an esterified carboxyl group bound to an acyclic carbon atom
40Succinic acid esters
C07C 69/708
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
69Esters of carboxylic acids; Esters of carbonic or haloformic acids
66Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
67of saturated acids
708Ethers
C07D 273/02
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
273Heterocyclic compounds containing rings having nitrogen and oxygen atoms as the only ring hetero atoms, not provided for by groups C07D261/00 - C07D271/00
02having two nitrogen atoms and only one oxygen atom
C07D 281/18
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
281Heterocyclic compounds containing rings of more than six members having one nitrogen atom and one sulfur atom as the only ring hetero atoms
18Eight-membered rings
C07D 307/33
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
307Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
02not condensed with other rings
26having one double bond between ring members or between a ring member and a non-ring member
30with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
32Oxygen atoms
33in position 2, the oxygen atom being in its keto or unsubstituted enol form
C07D 319/06
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
319Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
041,3-Dioxanes; Hydrogenated 1,3-dioxanes
06not condensed with other rings
Applicants НЬЮРОУВИВ ФАРМАСЬЮТИКАЛ АБ
Inventors Элмер Эскил
Ханссон Магнус Йоаким
Эингер Карл Хенрик Йоханнес
Мосс Стивен
Agents Медведев Валерий Николаевич
Priority Data PA 2014 70187 08.04.2014 DK
Title
(RU) ПРОЛЕКАРСТВА ЯНТАРНОЙ КИСЛОТЫ ДЛЯ ПОВЫШЕНИЯ ПРОИЗВОДСТВА ATP
Abstract
(RU)

Настоящее изобретение относится к новым клеточно-проницаемым сукцинатам и клеточно-проницаемым предшественникам сукцината, направленным на увеличение производства АТР в митохондриях. Основная часть АТР, продуцируемая и используемая в эукариотической клетке, образуется в результате митохондриального окислительного фосфорилирования, процесса, для которого высокоэнергетические электроны предоставляются циклом Кребса. Не все промежуточные продукты цикла Кребса являются легко проницаемыми в клеточные мембраны, одним из которых является сукцинат. Предоставление новых клеточно-проницаемых сукцинатов предусматривается для возможности прохождения через клеточную мембрану и, таким образом, клеточно-проницаемые сукцинаты могут быть использованы для увеличения митохондриального производства АТР.


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